Kassa Roza Teshome
Department of Nursing and Midwifery, School of Allied Health Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
BMC Res Notes. 2018 Feb 20;11(1):145. doi: 10.1186/s13104-018-3244-6.
Although cervical cancer is a preventable disease, it remains a leading cause of death among women in developing countries. In this unmatched case control design, 55 cases and 109 controls were included. The main objective of this study was to assess the risk factors of precancerous cervical lesion in Adama town.
A total of 164 participants were recruited in this study. Of the 109 controls, 64 (61%) and 41 (39%) of cases were using oral contraception. Women who were using oral contraception were two times at risk for developing precancerous cervical lesion than who were not using (COR = 2.059 95% CI 1.006, 4.216; AOR = 2.342). Out of 55 cases, 21 (38.2%) cases had a history STI and out of 109 controls, 24 (22.2%) controls had a history of STI. It was revealed that STI has a significant association for developing of precancerous lesion. Women who had a history of STI were two times at risk of developing precancerous cervical lesion than who had no (COR = 2.187; AOR = 2.485). It was found that initiation of sexual intercourse before the age of 15 years has 5.6 risks to develop precancerous cervical lesion (COR = 5.625 AOR = 6.703).
尽管宫颈癌是一种可预防的疾病,但它仍是发展中国家女性死亡的主要原因。在这项非匹配病例对照设计中,纳入了55例病例和109例对照。本研究的主要目的是评估阿达马镇宫颈癌前病变的危险因素。
本研究共招募了164名参与者。在109名对照中,64例(61%)和41例(39%)使用口服避孕药。使用口服避孕药的女性患宫颈癌前病变的风险是未使用者的两倍(校正比值比=2.059,95%置信区间1.006,4.216;调整后比值比=2.342)。在55例病例中,21例(38.2%)有性传播感染史,在109名对照中,24例(22.2%)有性传播感染史。结果显示,性传播感染与癌前病变的发生有显著关联。有性传播感染史的女性患宫颈癌前病变的风险是无此病史者的两倍(校正比值比=2.187;调整后比值比=2.485)。研究发现,15岁前开始性行为患宫颈癌前病变的风险为5.6(校正比值比=5.625,调整后比值比=6.703)。