Palm U, Chalah M A, Créange A, Lefaucheur J-P, Ayache S S
EA 4391, excitabilité nerveuse et thérapeutique, université Paris-Est-Créteil, 61, avenue du Général-de-Gaulle, 94000 Créteil, France; Department of Psychiatry, Psychotherapy and Psychosomatics, Ludwig-Maximilian University, Geschwister-Scholl Platz 1, 80539 Munich, Germany.
EA 4391, excitabilité nerveuse et thérapeutique, université Paris-Est-Créteil, 61, avenue du Général-de-Gaulle, 94000 Créteil, France; Service de physiologie-explorations fonctionnelles, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris, 31, rue du Parc, 94000 Créteil, France.
Encephale. 2018 Dec;44(6):565-567. doi: 10.1016/j.encep.2017.11.004. Epub 2018 Feb 17.
Fatigue and depression are frequent symptoms in multiple sclerosis (MS). Both are overlapping and shadowing each other and may impair the quality of life. For detection of depression symptoms in MS, the Multiple Sclerosis Depression Rating Scale (MSDRS) has been proposed recently. Here, we compare the performance of MSDRS in MS patients with and without fatigue to that of established rating scales, i.e. Hospital Anxiety and Depression Scale and Beck Depression Inventory. Twenty-nine MS patients were screened for fatigue and depression symptoms. Patients with fatigue showed significantly higher depression scores compared to patients without fatigue, whereas the number of depressed patients did not differ between the two groups. MSDRS seems to have higher sensitivity to detect severe depression than established rating scales. However, one should keep in mind that such a finding might be due to an increase in false positive cases when using MSDRS. Implementing this scale in future studies might be of help to enhance the understanding of its potential utility.
疲劳和抑郁是多发性硬化症（MS）的常见症状。两者相互重叠且相互影响，可能会损害生活质量。为了检测MS患者的抑郁症状，最近有人提出了多发性硬化症抑郁评定量表（MSDRS）。在此，我们将有疲劳和无疲劳的MS患者中MSDRS的表现与既定评定量表（即医院焦虑抑郁量表和贝克抑郁量表）的表现进行比较。对29例MS患者进行了疲劳和抑郁症状筛查。有疲劳的患者与无疲劳的患者相比，抑郁得分显著更高，而两组中抑郁患者的数量没有差异。MSDRS在检测重度抑郁方面似乎比既定评定量表具有更高的敏感性。然而，应该记住，这样的发现可能是由于使用MSDRS时假阳性病例增加所致。在未来的研究中应用该量表可能有助于增强对其潜在效用的理解。
