Sharabi Sivan, Bassal Ravit, Friedman Nehemya, Drori Yaron, Alter Hadar, Glatman-Freedman Aharona, Hindiyeh Musa, Cohen Daniel, Mendelson Ella, Shohat Tamy, Mandelboim Michal
Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Oncotarget. 2017 Dec 22;9(5):6623-6629. doi: 10.18632/oncotarget.23601. eCollection 2018 Jan 19.
While infection with influenza A viruses has been extensively investigated, infections with influenza B viruses which are commonly categorized into the highly homologous Victoria and Yamagata lineages, are less studied, despite their considerable virulence. Here we used RT-PCR assays, hemagglutination inhibition assays and antibody titers to determine the levels of influenza B infection. We report of high influenza B Victoria virus prevalence in the 2015-16 winter season in Israel, affecting approximately half of the Israeli population. We further show that the Victoria B virus infected individuals of all ages and that it was present in the country throughout the entire winter season. The vaccine however included the inappropriate Yamagata virus. We propose that a quadrivalent vaccine, that includes both Yamagata and Victoria lineages, should be considered for future influenza vaccination.
虽然甲型流感病毒感染已得到广泛研究，但乙型流感病毒感染的研究较少，尽管其毒性相当大。乙型流感病毒通常分为高度同源的维多利亚和山形谱系。在这里，我们使用逆转录聚合酶链反应（RT-PCR）检测、血凝抑制试验和抗体滴度来确定乙型流感感染水平。我们报告了2015 - 16年冬季以色列乙型维多利亚流感病毒的高流行率，约影响了一半的以色列人口。我们进一步表明，维多利亚乙型病毒感染了所有年龄段的人，并且在整个冬季都在该国存在。然而，疫苗包含的是不适当的山形病毒。我们建议，未来的流感疫苗接种应考虑使用包含山形和维多利亚谱系的四价疫苗。
