Velleja Research, Viale Lunigiana 23, 20125, Milan, Italy.
Probiotics Antimicrob Proteins. 2019 Mar;11(1):332-334. doi: 10.1007/s12602-018-9398-7.
The neutral outcome of the recently reported school-based trial of probiotic K12 (The effect of the oral probiotic Streptococcus salivarius K12 on group A streptococcus pharyngitis: a pragmatic trial in schools) can be attributed at least partially to several readily identifiable confounding factors. Mainly, the execution and outcome were negatively impacted by (a) the suboptimal efficacy and frequency of K12 administration, (b) the failure both clinically and microbiologically to adequately diagnose and distinguish active group A streptococci (GAS) pharyngitis from harmless GAS carriage, and (c) the exceptionally low occurrence of GAS in this population at the time of the probiotic intervention due to recent high-intensity antibiotic exposure.
最近报道的一项基于学校的益生菌 K12 试验（口服益生菌唾液链球菌 K12 对 A 组链球菌咽炎的影响：学校中的实用试验）的中性结果至少部分归因于几个易于识别的混杂因素。主要是，执行和结果受到以下因素的负面影响：(a) K12 给药的效果和频率不理想，(b) 在临床上和微生物学上未能充分诊断和区分活动性 A 组链球菌（GAS）咽炎和无害 GAS 携带，以及 (c) 在益生菌干预时，由于最近高强度抗生素暴露，该人群中 GAS 的发生率异常低。
