Nutrition Department, Brazilian National Cancer Institute-INCA, Rio de Janeiro, Brazil.
Post-Graduate Program in Oncology, Brazilian National Cancer Institute-INCA, Rio de Janeiro, Brazil.
Nutr Diet. 2018 Jul;75(3):263-270. doi: 10.1111/1747-0080.12414. Epub 2018 Feb 21.
Assess the influence of chemoradiotherapy on the nutritional status, functional capacity and quality of life (QoL), associating these indicators at baseline with toxicity and interruption of oncologic treatment in women with cervical cancer.
Prospective cohort study performed on 49 women diagnosed with cervical cancer, who underwent treatment between August 2015 and January 2016. For data collection, two appointments were conducted by the lead researcher: the first occurred the day before the first chemotherapy session (T0) and the other at the end of chemotherapy session (T1). Nutritional status was measured by anthropometry (weight, height, mid-upper arm circumference and triceps skinfold thickness) and computed tomography (skeletal muscle index-SMI), functional capacity by handgrip strength (HGS) and Karnofsky Performance Status (KPS), and application of QoL questionnaire (EORTC QLQ-C30).
The average age was 45 ± 13.8 years and 81.6% of the women were diagnosed in stages II and III. There was significant reduction in HGS, KPS and QoL between T0 and T1, in addition to a significant QoL reduction according to worsening nutritional status. The interruption of chemotherapy was significantly associated with the variables of nutritional status assessed at baseline. Women who interrupted treatment due to acute toxicity also had a significant lower median SMI than those who concluded the treatment and 83% of these patients presented cachexia.
Chemoradiotherapy treatment in patients with cervical cancer had changed negative nutritional parameters, function capacity and QoL, and poor nutritional status at baseline was associated with chemotherapy interruption.
评估放化疗对营养状况、功能能力和生活质量（QoL）的影响，并将这些基线指标与宫颈癌女性的毒性和肿瘤治疗中断相关联。
这是一项前瞻性队列研究，纳入了 49 名 2015 年 8 月至 2016 年 1 月期间接受治疗的宫颈癌患者。主要研究者在两次就诊时收集数据：第一次就诊在第一次化疗前一天（T0），第二次就诊在化疗结束时（T1）。营养状况通过人体测量学（体重、身高、上臂中部周长和三头肌皮褶厚度）和计算机断层扫描（骨骼肌指数-SMI）进行评估，功能能力通过握力（HGS）和 Karnofsky 表现状态（KPS）进行评估，生活质量通过应用 EORTC QLQ-C30 问卷进行评估。
患者的平均年龄为 45±13.8 岁，81.6%的患者诊断为 II 期和 III 期。与 T0 相比，T1 时 HGS、KPS 和 QoL 显著下降，此外，营养状况恶化与 QoL 显著下降相关。化疗中断与基线评估的营养状况变量显著相关。因急性毒性而中断治疗的女性的中位 SMI 显著低于完成治疗的女性，83%的患者出现恶病质。
宫颈癌患者的放化疗治疗改变了负面的营养参数、功能能力和生活质量，并且基线时的不良营养状况与化疗中断相关。
