应激反应途径基因中的遗传变异与海洛因长期戒断有关。
Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.
作者信息
Levran Orna, Peles Einat, Randesi Matthew, Correa da Rosa Joel, Shen Pei-Hong, Rotrosen John, Adelson Miriam, Kreek Mary Jeanne
机构信息
The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA.
Dr Miriam & Sheldon G Adelson Clinic for Drug Abuse Treatment & Research, Tel Aviv Elias Sourasky Medical Center, 1 Henrietta Szold St, Tel-Aviv, 64924, Israel.
出版信息
Pharmacogenomics. 2018 Mar;19(4):333-341. doi: 10.2217/pgs-2017-0179. Epub 2018 Feb 21.
AIM
This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment.
METHODS
Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923).
RESULTS
SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment.
CONCLUSION
This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.
目的
本研究评估与应激相关基因的遗传变异是否与未接受长期美沙酮治疗的海洛因成瘾者延长戒断时间相关。
方法
比较了有海洛因成瘾史的受试者（未接受激动剂治疗，n = 129；或接受美沙酮维持治疗，n = 923）中30个基因的117个多态性的频率。
结果
促肾上腺皮质激素释放激素结合蛋白（CRHBP）下游的单核苷酸多态性（SNP）rs1500以及SNP rs10482672（NR3C1）和rs4234955（NPY1R/NPY5R）的相互作用与未接受激动剂治疗时延长戒断时间显著相关。
结论
本研究表明，与应激相关基因的变异性可能有助于某些受试者延长海洛因戒断时间，这可能是由于对压力的恢复力较高。
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