进一步的证据表明 、 和 变体与阿片类药物依赖有关。
Further evidence for the association of , and variants with opioid dependence.
机构信息
Laboratory of The Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Department of Psychiatry, Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100DD Amsterdam, The Netherlands.
出版信息
Pharmacogenomics. 2020 Aug;21(13):903-917. doi: 10.2217/pgs-2020-0045. Epub 2020 Aug 6.
Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: / rs4691910/rs1893679, / rs4691910/rs3136541 and rs9807208/rs3136541. This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.
海洛因成瘾是一种慢性、复发性疾病，具有遗传和环境因素的影响，包括药物诱导的因素。压力会影响成瘾的发展。本研究旨在确定与阿片类药物依赖（OD）相关的应激相关基因变异是否存在关联。在 597 名荷兰受试者中，分析了 26 个基因中的 120 个变异。患者包括 281 名接受美沙酮维持治疗且伴有或不伴有海洛因辅助治疗的 OD 患者，以及 316 名对照。在七个基因中的 12 个 SNP 与 OD 具有显著的关联。通过相互作用效应，发现了三个 SNP 对的实验性显著关联（p < 0.05）：/ rs4691910/rs1893679、/ rs4691910/rs3136541 和 rs9807208/rs3136541。本研究为先前关于应激相关变异与海洛因依赖相关的报告提供了更多证据。
Zotero 插件