内源性阿片拮抗剂可抑制β-内啡肽诱导的生长激素分泌，但不抑制催乳素分泌。

The beta-endorphin-induced secretion of growth hormone but not of prolactin is inhibited by an endogenous opioid antagonist.

作者信息

Collado-Escobar D, Rovati L C, Ganzetti I, Cocchi D, Panerai A E, Li C H

出版信息

Eur J Pharmacol. 1986 Oct 7;129(3):385-7. doi: 10.1016/0014-2999(86)90453-x.

Abstract

The naturally occurring peptide human beta-endorphin-(1-27) (h beta-EP-(1-27) has been shown to antagonize beta-endorphin (h beta-EP)-induced analgesia. We have evaluated the effects of the fragment on h beta-EP-induced growth hormone (GH) and prolactin (PRL) release. It inhibited beta-EP-induced GH release in a dose-related way but left beta-EP-induced PRL stimulation unchanged.

摘要

天然存在的肽类人β-内啡肽-（1-27）（hβ-EP-（1-27））已被证明可拮抗β-内啡肽（hβ-EP）诱导的镇痛作用。我们评估了该片段对hβ-EP诱导的生长激素（GH）和催乳素（PRL）释放的影响。它以剂量相关的方式抑制β-EP诱导的GH释放，但β-EP诱导的PRL刺激作用保持不变。