β-内啡肽-（1-27）是β-内啡肽镇痛的拮抗剂。
beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
作者信息
Hammonds R G, Nicolas P, Li C H
出版信息
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1389-90. doi: 10.1073/pnas.81.5.1389.
Abstract
beta h-Endorphin-(1-27), a naturally occurring fragment of human beta-endorphin (beta h-endorphin), diminishes the analgesic effect of beta h-endorphin when coinjected intra-cerebroventricularly into mice. A parallel shift in the dose-response curve of beta h-endorphin in the presence of beta h-endorphin-(1-27) suggests competition at the same site. The potency of beta h-endorphin-(1-27) in antagonizing analgesia is greater than 4 times greater than that of the opiate antagonist naloxone.
摘要
βh-内啡肽-（1-27）是人类β-内啡肽（βh-内啡肽）的一种天然存在的片段，当与βh-内啡肽共同脑室内注射到小鼠体内时，会减弱βh-内啡肽的镇痛作用。在存在βh-内啡肽-（1-27）的情况下，βh-内啡肽剂量-反应曲线的平行移动表明在同一部位存在竞争。βh-内啡肽-（1-27）拮抗镇痛的效力比阿片拮抗剂纳洛酮的效力大4倍以上。
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