Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA.
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Immunity. 2018 Feb 20;48(2):214-226. doi: 10.1016/j.immuni.2018.02.010.
Considerable advances have been made in recent years in understanding the generation and function of memory T cells. Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. Here we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regulation, and longevity may fail to fit into small groups of "memory subsets." Rather, the properties of individual memory T cells fall on a continuum within each of these and other parameters. We discuss how this continuum influences the way that the efficacy of vaccination is assessed, as well as the suitability of a memory population for protective immunity.
近年来，人们在理解记忆 T 细胞的产生和功能方面取得了重大进展。记忆 T 细胞通常根据表型定义划分为离散的亚群，这些定义暗示了它们在免疫中的不同作用。在这里，我们考虑该领域的新进展，并重点关注记忆细胞在其迁移、代谢、表观遗传调控和寿命方面的新兴差异如何无法归入少数“记忆亚群”。相反，单个记忆 T 细胞的特性在这些和其他参数中的每一个参数内都处于连续统上。我们讨论了这种连续统如何影响疫苗效力评估的方式，以及记忆群体对保护性免疫的适宜性。
