皮肤中的驻留记忆T细胞介导对黑色素瘤的持久免疫。
Resident memory T cells in the skin mediate durable immunity to melanoma.
作者信息
Malik Brian T, Byrne Katelyn T, Vella Jennifer L, Zhang Peisheng, Shabaneh Tamer B, Steinberg Shannon M, Molodtsov Aleksey K, Bowers Jacob S, Angeles Christina V, Paulos Chrystal M, Huang Yina H, Turk Mary Jo
机构信息
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Parker Institute for Cancer Immunotherapy and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Sci Immunol. 2017 Apr 14;2(10). doi: 10.1126/sciimmunol.aam6346.
Tissue-resident memory T (T) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific T cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. These cells expressed CD103, CD69, and CLA (cutaneous lymphocyte antigen), but lacked PD-1 (programmed cell death protein-1) or LAG-3 (lymphocyte activation gene-3), and were capable of making IFN-γ (interferon-γ). CD103 expression on CD8 T cells was required for the establishment of T cells in the skin but was dispensable for vitiligo development. CD103 CD8 T cells were critical for protection against melanoma rechallenge. This work establishes that CD103-dependent T cells play a key role in perpetuating antitumor immunity.
组织驻留记忆性T（T）细胞在传染病环境中已得到广泛表征；然而，它们在介导癌症免疫中的作用仍不清楚。我们报告称，皮肤驻留记忆性T细胞对黑色素瘤的反应是自身免疫性白癜风自然产生的结果。黑色素瘤抗原特异性T细胞主要驻留在黑素细胞缺失的毛囊中，并且在没有从淋巴区室再循环或补充的情况下得以维持。这些细胞表达CD103、CD69和CLA（皮肤淋巴细胞抗原），但缺乏PD-1（程序性细胞死亡蛋白1）或LAG-3（淋巴细胞活化基因3），并且能够产生IFN-γ（干扰素γ）。CD8 T细胞上CD103的表达是T细胞在皮肤中驻留所必需的，但对白癜风的发展并非必需。CD103⁺ CD8 T细胞对于抵抗黑色素瘤再次攻击至关重要。这项工作表明，依赖CD103的T细胞在维持抗肿瘤免疫中起关键作用。
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