Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Development. 2018 Mar 14;145(6):dev158865. doi: 10.1242/dev.158865.
Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the major role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear. Here, we show that glycogen metabolism is regulated in a tissue-specific manner under starvation conditions in the fruit fly The mobilization of fat body glycogen in larvae is independent of Adipokinetic hormone (Akh, the glucagon homolog) but is regulated by sugar availability in a tissue-autonomous manner. Fat body glycogen plays a crucial role in the maintenance of circulating sugars, including trehalose, under fasting conditions. These results demonstrate the importance of fat body glycogen as a metabolic safeguard in .
适应食物供应的变化是生存的核心挑战。葡萄糖是能量产生的重要资源，因此许多生物合成并保留糖储存分子。在昆虫中，葡萄糖以两种不同的形式储存：二糖海藻糖和支链聚合物糖原。糖原在包括肌肉和脂肪体在内的几种组织中合成和储存。尽管脂肪体作为能量代谢中心具有重要作用，但脂肪体糖原含量的重要性仍不清楚。在这里，我们表明在果蝇中，饥饿条件下的糖原代谢以组织特异性的方式受到调节。幼虫中脂肪体糖原的动员不依赖于促肾上腺素释放激素（Akh，胰高血糖素同源物），而是以组织自主的方式受糖可用性的调节。脂肪体糖原在禁食条件下维持循环糖（包括海藻糖）中起着至关重要的作用。这些结果表明脂肪体糖原作为代谢保护的重要性在 中。
