() is a pivotal gene in the lipid synthesis pathway and plays a crucial role in insect energy metabolism. , as one of the major agricultural pests, requires identification of new targets to control or reduce its reproductive capacity for effective locust pest management strategies. In this study, we focused on and identified as a potential target gene with functional significance in lipid metabolism and reproduction based on sequence characteristics analysis and tissue-expression patterns of five genes. Subsequently, through RNA interference (RNAi) targeting expression, we assessed alterations in lipid and carbohydrate metabolism-related gene expression levels, lipid and carbohydrate contents, ovarian development, and reproductive capacity using experimental techniques such as RT-qPCR, ELISA, and morphological observations. Our findings revealed that interference with upregulated genes involved in lipid degradation, including -1, -2, , and , while significantly decreasing the TAG content and fat accumulation. At the level of carbohydrate metabolism, silencing led to significant upregulation of key genes and in the synthesis pathway, resulting in increased glycogen and trehalose content. In addition, interference resulted in a significant reduction of mRNA expression level sand protein content in , followed by delayed ovarian development and reduced egg production. This further confirms that impaired function prompts to enhance lipid degradation and sugar storage to maintain the energy balance, while reducing the energy investment into reproduction. Collectively, the results of this study suggest that can serve as a novel molecular target for controlling