奥沙利铂诱发胃癌患者肝窦阻塞综合征：一例报告
Oxaliplatin-induced hepatic sinusoidal obstruction syndrome in a patient with gastric cancer: A case report.
作者信息
Liu Fang, Cao Xin, Ye Jin, Pan Xiaoli, Kan Xuefeng, Song Yuhu
机构信息
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
出版信息
Mol Clin Oncol. 2018 Mar;8(3):453-456. doi: 10.3892/mco.2017.1540. Epub 2017 Dec 18.
Oxaliplatin is a platinum-based antineoplastic agent used in cancer chemotherapy. Oxaliplatin-induced hepatic sinusoidal obstruction syndrome (HSOS) has been reported in the context of chemotherapy for liver metastasis of colorectal cancer. However, to the best of our knowledge, there is no report of oxaliplatin-associated HSOS in patients with gastric cancer. The present study reported a patient with gastric cancer who received proximal gastrectomy and oxaliplatin-containing chemotherapy. Contrast-enhanced computed tomography revealed that liver parenchyma appeared heterogeneous and demonstrated hypoattenuation in the portal phase. In dynamic contrast-enhanced magnetic resonance imaging, hypointense heterogeneity was demonstrated in the portal-venous phase. Pathological examination indicated distinctive multifocal sinusoidal dilatation. In conclusion, the present report indicated a case of oxaliplatin-induced HSOS in a patient with gastric cancer who received oxaliplatin-contained chemotherapy.
奥沙利铂是一种用于癌症化疗的铂类抗肿瘤药物。在结直肠癌肝转移化疗过程中，已有奥沙利铂诱导的肝窦阻塞综合征（HSOS）的报道。然而，据我们所知，尚无胃癌患者发生奥沙利铂相关HSOS的报道。本研究报告了一名接受近端胃切除术及含奥沙利铂化疗的胃癌患者。增强计算机断层扫描显示肝实质呈不均匀性改变，在门静脉期表现为低密度。动态对比增强磁共振成像显示门静脉期呈低信号不均匀性。病理检查显示有明显的多灶性肝窦扩张。总之，本报告指出了一例接受含奥沙利铂化疗的胃癌患者发生奥沙利铂诱导的HSOS。
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