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[当前针对小肾肿块的指南导向随访:应用的风险评分及未来展望]

[Current guideline-oriented follow-up of small renal masses : Applied risk scores and future outlook].

作者信息

Stühler V, Kruck S, Todenhöfer T, Stenzl A, Bedke J

机构信息

Klinik für Urologie, Eberhard Karls Universität, Hoppe-Seyler-Str. 3, 72070, Tübingen, Deutschland.

出版信息

Urologe A. 2018 Mar;57(3):300-306. doi: 10.1007/s00120-018-0586-6.

DOI:10.1007/s00120-018-0586-6
PMID:29468281
Abstract

After surgical resection of renal cell carcinoma by laparoscopic or open partial or complete nephrectomy, medical aftercare based on the current guidelines should be provided. This seems desirable, especially because one third of patients after initial curative tumor resection develop recurrence over time. In this article, the current recommendations for follow-up will be systematically presented based on the accepted German S3 guideline and the European Association of Urology (EAU) guideline. Another point of this article will be the presentation of the currently applied risk scores to predict prognosis with a focus on molecular markers. The goal is to improve the prediction of survival and to facilitate risk-adjusted aftercare.

摘要

通过腹腔镜或开放手术进行部分或完全肾切除术后,应根据当前指南提供医学后续护理。这似乎是可取的,特别是因为三分之一的患者在最初的根治性肿瘤切除术后会随着时间的推移出现复发。在本文中,将根据公认的德国S3指南和欧洲泌尿外科学会(EAU)指南系统地介绍当前的随访建议。本文的另一个要点是介绍目前应用的风险评分,以预测预后,重点是分子标志物。目标是改善生存预测并促进风险调整后的后续护理。

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Urologe A. 2018 Mar;57(3):300-306. doi: 10.1007/s00120-018-0586-6.
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Systemic therapy in metastatic renal cell carcinoma.转移性肾细胞癌的全身治疗
World J Urol. 2017 Feb;35(2):179-188. doi: 10.1007/s00345-016-1868-5. Epub 2016 Jun 9.
2
A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma.一种基于CpG甲基化的检测方法用于预测透明细胞肾细胞癌的生存率。
Nat Commun. 2015 Oct 30;6:8699. doi: 10.1038/ncomms9699.
3
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma.纳武单抗与依维莫司治疗晚期肾细胞癌的比较
N Engl J Med. 2015 Nov 5;373(19):1803-13. doi: 10.1056/NEJMoa1510665. Epub 2015 Sep 25.
4
Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron.基于与肾单位近端小管基因表达相似性的肾透明细胞癌生存预测。
Eur Urol. 2015 Dec;68(6):1016-20. doi: 10.1016/j.eururo.2015.05.045. Epub 2015 Jun 12.
5
ClearCode34: A prognostic risk predictor for localized clear cell renal cell carcinoma.ClearCode34:一种局限性透明细胞肾细胞癌的预后风险预测指标。
Eur Urol. 2014 Jul;66(1):77-84. doi: 10.1016/j.eururo.2014.02.035. Epub 2014 Feb 25.
6
DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome.SLC16A3 启动子的 DNA 甲基化调控人乳酸转运体 MCT4 在肾细胞癌中的表达,影响临床结局。
Clin Cancer Res. 2013 Sep 15;19(18):5170-81. doi: 10.1158/1078-0432.CCR-13-1180. Epub 2013 Jul 23.
7
The Karakiewicz nomogram is the most useful clinical predictor for survival outcomes in patients with localized renal cell carcinoma.卡拉克维茨列线图是预测局限性肾细胞癌患者生存结局最有用的临床预测因子。
Cancer. 2011 Dec 1;117(23):5314-24. doi: 10.1002/cncr.26193. Epub 2011 May 12.
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Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns.通过共识聚类对透明细胞肾细胞癌进行分子分层揭示了不同的亚型和生存模式。
Genes Cancer. 2010 Feb 1;1(2):152-163. doi: 10.1177/1947601909359929.
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CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value.CD147和VEGF在晚期肾细胞癌中的表达及其预后价值。
Cancer Invest. 2009 Aug;27(7):788-93. doi: 10.1080/07357900802709167.
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