Kammerer S, du Mesnil de Rochemont R, Wagner M, You S -J, Tritt S, Mueller-Eschner M, Keil F C, Lauer A, Berkefeld J
Institute of Neuroradiology, University Hospital of the Goethe-University Frankfurt, Goethe University Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
Cardiovasc Intervent Radiol. 2018 May;41(5):699-705. doi: 10.1007/s00270-018-1901-8. Epub 2018 Feb 21.
Intra-arterial therapy of acute ischemic stroke has developed rapidly in recent years. Due to proven efficacy in randomized trials, stent retrievers were replacing first-generation thrombectomy devices and have been defined as method of choice. However, aspiration catheters or a combination of several techniques have shown promising rates of successful recanalizations. To create a basis for comparison of the new approaches according to real-world data, we determined the first pass recanalization rate of an evidence-based standard technique with the use of a stent retriever in combination with a balloon-guiding catheter. The assessment was based on the number of required passages and reperfusion rate, but not on clinical results.
Patients from our institution with anterior circulation occlusions and mechanical thrombectomy by using stent retrievers in combination with balloon-guiding catheters were analyzed retrospectively. Reperfusion was graded with the "thrombolysis in cerebral infarction" (TICI) classification on post-interventional angiograms. Additionally, the number of passes and the duration of the recanalization procedure were recorded.
Between 2014 and July 2017, 201 patients met the inclusion criteria. Successful recanalization, defined as a TICI scale 2b/3, was 91% (TICI 2b was achieved in 44% and TICI 3 in 47%) after the procedure. After the first passage, successful recanalization was achieved in 65% of the patients. Mean number of passes was 1.4 (1-5 passes) for all patients. Median duration of the procedure was 49 min (0:11-2:35 h).
Even a standard thrombectomy technique with the use of a stent retriever together with a balloon-guiding catheter provides reasonable recanalization rates with only one passage. The results can be taken as benchmark for alternative and more complex techniques.
近年来,急性缺血性卒中的动脉内治疗发展迅速。由于在随机试验中已证实其疗效,支架取栓器正在取代第一代血栓切除术设备,并已被定义为首选方法。然而,抽吸导管或几种技术的联合应用已显示出有希望的成功再通率。为了根据真实世界数据为比较新方法建立基础,我们确定了使用支架取栓器联合球囊引导导管的循证标准技术的首次通过再通率。评估基于所需通过次数和再灌注率,而非临床结果。
对我院采用支架取栓器联合球囊引导导管进行机械血栓切除术治疗前循环闭塞的患者进行回顾性分析。在介入后血管造影上采用“脑梗死溶栓”(TICI)分类对再灌注进行分级。此外,记录通过次数和再通手术持续时间。
2014年至2017年7月期间,201例患者符合纳入标准。手术后成功再通(定义为TICI 2b/3级)率为91%(44%达到TICI 2b级,47%达到TICI 3级)。首次通过后,65%的患者实现了成功再通。所有患者的平均通过次数为1.4次(1 - 5次)。手术的中位持续时间为49分钟(0:11 - 2:35小时)。
即使是使用支架取栓器联合球囊引导导管的标准血栓切除术技术,单次通过也能提供合理的再通率。该结果可作为替代和更复杂技术的基准。