镓-多柔比星PET-CT成像在颈动脉体副神经节瘤中的应用

Ga-DOTATATE PET-CT imaging in carotid body paragangliomas.

作者信息

Şimşek Duygu Has, Şanlı Yasemin, Kuyumcu Serkan, Başaran Bora, Mudun Ayşe

机构信息

Department of Nuclear Medicine, Şişli Hamidiye Etfal Training and Research Hospital, Halaskargazi Street, Şişli, 34371, Istanbul, Turkey.

Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

出版信息

Ann Nucl Med. 2018 May;32(4):297-301. doi: 10.1007/s12149-018-1242-3. Epub 2018 Feb 21.

DOI:10.1007/s12149-018-1242-3

PMID:29468487

Abstract

OBJECTIVE

The aim of this study was to present our experience in the baseline evaluation of carotid body paragangliomas (CBP) with Ga-DOTATATE PET-CT.

METHODS

Five patients (4F, 1M; age 24-73 years) with CBPs who underwent Ga-DOTATATE PET-CT scan before the treatment were evaluated retrospectively. PET-CT images were analyzed visually as well as semiquantitatively, with measurement of maximum standardized uptake value (SUV).

RESULTS

All patients had unilateral CBP lesion, showed intense Ga-DOTATATE uptake in PET-CT. Additionally, Ga-DOTATATE avid lesions were found in two patients. One of them had focal intense uptake in thyroid gland and frontal cerebrum. The other one had intense uptake in bone and adrenal mass. Four patients were operated for unilateral primary CBP. Last patient was treated with peptide receptor radionuclide therapy (Lu-DOTATATE) for both metastatic pheochromocytoma and CBP.

CONCLUSIONS

Ga-DOTATATE PET-CT is a valuable imaging modality for staging of CBPs, detecting unknown lesions and changing the management of patients. It is also useful in demonstrating expression of SSTRs for PRRT opportunity.

摘要

目的

本研究的目的是介绍我们使用镓[⁶⁸Ga] DOTATATE PET-CT对颈动脉体副神经节瘤（CBP）进行基线评估的经验。

方法

回顾性评估5例（4例女性，1例男性；年龄24 - 73岁）接受治疗前镓[⁶⁸Ga] DOTATATE PET-CT扫描的CBP患者。对PET-CT图像进行了视觉和半定量分析，并测量了最大标准化摄取值（SUV）。

结果

所有患者均有单侧CBP病变，在PET-CT中显示镓[⁶⁸Ga] DOTATATE摄取强烈。此外，在2例患者中发现了镓[⁶⁸Ga] DOTATATE摄取活跃的病变。其中1例在甲状腺和额叶有局灶性强烈摄取。另一例在骨骼和肾上腺肿块中有强烈摄取。4例患者接受了单侧原发性CBP手术。最后1例患者接受了肽受体放射性核素治疗（镥[¹⁷⁷Lu] DOTATATE），用于转移性嗜铬细胞瘤和CBP。