Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400, Copenhagen, Denmark.
Department of Clinical Epidemiology, Aarhus University, Olof Palmes Allé 43-45, 8200, Aarhus N, Denmark.
Curr Environ Health Rep. 2018 Mar;5(1):20-33. doi: 10.1007/s40572-018-0174-3.
The purpose of this review is to systematically review the literature linking di-2-ethylhexyl phthalate (DEHP) exposure with effects on reproductive health in adult males.
Thirty-three papers were included of which 28 were cross-sectional. Twenty-one papers investigated semen samples, 18 investigated reproductive hormones, and three studies investigated time to pregnancy. Studies revealed some but inconsistent indications that higher urinary DEHP metabolite levels are associated with an increase in the proportion of spermatozoa with damaged DNA and to a decrease in sperm concentration and motility. A negative association between DEHP metabolites and testosterone levels was more consistent. DEHP metabolites do not seem to be associated with a delay in time to pregnancy, but data are sparse. The studies on DEHP exposure and reproductive biomarkers in men converge to support the hypothesis that DEHP exposure is related to impaired male reproductive function. Longitudinal studies are needed to establish if the observed associations are causal.
本文旨在系统地回顾文献，探讨邻苯二甲酸二（2-乙基己基）酯（DEHP）暴露与成年男性生殖健康影响之间的关系。
共纳入 33 篇论文，其中 28 篇为横断面研究。21 篇研究了精液样本，18 篇研究了生殖激素，3 项研究调查了妊娠时间。研究表明，较高的尿液 DEHP 代谢物水平与受损 DNA 的精子比例增加以及精子浓度和活力降低有关，但结果并不一致。DEHP 代谢物与睾酮水平之间的负相关更为一致。DEHP 代谢物似乎与妊娠时间延迟无关，但数据有限。这些关于 DEHP 暴露与男性生殖生物标志物的研究结果支持 DEHP 暴露与男性生殖功能受损有关的假设。需要进行纵向研究以确定观察到的相关性是否具有因果关系。
