School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Int J Environ Res Public Health. 2022 May 9;19(9):5742. doi: 10.3390/ijerph19095742.
Phthalate esters (PAEs) are ubiquitous in indoor environments as plasticizers in indoor products. Residences are often exposed to indoor PAEs in the form of gas, particles, settled dust, and surface phases. To reveal the mechanism behind the accumulation of PAEs in different tissues or organs such as the liver and the lungs when a person exposed to indoor PAEs with different phases, a whole-body physiologically based pharmacokinetic model for PAEs is employed to characterize the dynamic process of phthalates by different intake pathways, including oral digestion, dermal adsorption, and inhalation. Among three different intake pathways, dermal penetration distributed the greatest accumulation of DEHP in most of the organs, while the accumulative concentration through oral ingestion was an order of magnitude lower than the other two doses. Based on the estimated parameters, the variation of di-ethylhexyl phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) concentration in the venous blood, urine, the liver, the thymus, the pancreas, the spleen, the lungs, the brain, the heart, and the kidney for different intake scenarios was simulated. The simulated results showed a different accumulation profile of DEHP and MEHP in different organs and tissues and demonstrated that the different intake pathways will result in different accumulation distributions of DEHP and MEHP in organs and tissues and may lead to different detrimental health outcomes.
邻苯二甲酸酯（PAEs）作为室内产品中的增塑剂，在室内环境中无处不在。住宅经常以气体、颗粒、沉降灰尘和表面相的形式暴露于室内 PAEs 中。为了揭示当一个人暴露于不同相的室内 PAEs 时，PAEs 在肝脏和肺部等不同组织或器官中积累的机制，采用全身生理基于药代动力学模型来描述通过不同摄入途径（包括口服消化、皮肤吸收和吸入）的邻苯二甲酸酯的动态过程。在三种不同的摄入途径中，皮肤渗透分布使 DEHP 在大多数器官中的积累最大，而通过口服摄入的累积浓度比其他两种剂量低一个数量级。基于估计的参数，模拟了不同摄入情况下静脉血、尿液、肝脏、胸腺、胰腺、脾脏、肺、脑、心脏和肾脏中 DEHP 和 MEHP 浓度的变化。模拟结果表明，DEHP 和 MEHP 在不同器官和组织中的积累情况不同，表明不同的摄入途径会导致 DEHP 和 MEHP 在器官和组织中的积累分布不同，可能导致不同的健康危害后果。
