Department of Haematology, Royal North Shore Hospital, Kolling Institute, University of Sydney, St Leonards, Sydney, Australia.
Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC), Sydney, Australia.
Br J Haematol. 2018 Apr;181(1):97-101. doi: 10.1111/bjh.15146. Epub 2018 Feb 21.
Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.
由于低丙种球蛋白血症引起的免疫功能障碍在慢性淋巴细胞白血病（CLL）中很常见，感染是导致发病率和死亡率的主要因素。在 147 例 CLL 患者的队列中，与更晚期疾病相关的多种免疫球蛋白和免疫球蛋白 G（IgG）亚类缺乏的发生率更高（分别为 P<0.001 和 P<0.001）。多种免疫球蛋白和 IgG 亚类缺乏与无治疗生存时间（TFS）更短显著相关（分别为 P<0.001 和 P=0.006）。这些数据表明，疾病阶段和免疫功能障碍之间的相关性表明，免疫缺陷的某些方面与疾病严重程度相关，并且可能与 CLL 中的 TFS 更短相关。
