Consultant Clinical Microbiologist, National Virus Reference Laboratory, University College Dublin, Dublin, Ireland.
Consultant Haematologist, Sligo University Hospital, Sligo, Ireland.
Br J Haematol. 2018 Jun;181(5):579-589. doi: 10.1111/bjh.15133. Epub 2018 Feb 21.
In recent years there has been a paradigm shift in our understanding of the epidemiology and clinical features of hepatitis E virus (HEV) infection. Once classically described as an acute hepatitis associated with waterborne outbreaks in areas of poor sanitation, HEV is now recognised to be endemic in Europe and is probably zoonotic in origin. Evidence for transfusion-transmitted HEV has prompted the introduction of blood donor screening in a number of countries, but the risk to the haematology patient from food sources remains. The aim of this review therefore, is to equip the clinical haematologist with the knowledge required to diagnose HEV infection and to aid decision-making in patient management. The article also provides information on addressing patient concerns about their risk of acquiring hepatitis E and how this risk can be mitigated.
近年来，我们对戊型肝炎病毒（HEV）感染的流行病学和临床特征的认识发生了重大转变。HEV 曾被经典地描述为一种与卫生条件差的地区的水传播暴发相关的急性肝炎，但现在已被认为在欧洲流行，且可能起源于动物源性。有证据表明 HEV 可经输血传播，因此一些国家已开始对献血者进行筛查，但血液系统疾病患者仍有来自食物来源的感染风险。因此，本篇综述旨在使临床血液学家掌握诊断 HEV 感染所需的知识，并为患者管理中的决策提供帮助。本文还提供了有关解决患者对感染戊型肝炎风险的关注的信息，以及如何降低这种风险。
