School of Medicine, University of Leeds, Leeds, United Kingdom.
Leeds Institute of Data Analytics, University of Leeds, Leeds, United Kingdom.
Int J Cancer. 2018 Sep 15;143(6):1279-1286. doi: 10.1002/ijc.31337. Epub 2018 Mar 15.
Childhood cancer is increasing in prevalence whilst survival rates are improving. The prevalence of adult survivors of childhood cancer is consequently increasing. Many survivors suffer long-term consequences of their cancer treatment. Whilst many of these are well documented, relatively little is known about the mental health of survivors of childhood cancer. This article aimed to describe the prevalence and spectrum of mental health problems found in adult survivors of childhood cancer using a systematic review methodology. Our review included 67 articles, describing a number of problems, including depression, anxiety, behavioural problems and drug misuse. Factors increasing the likelihood of mental health problems included treatment with high-dose anthracyclines, cranial irradiation, diagnoses of sarcoma or central nervous system tumours and ongoing physical ill health. There were numerous limitations to the studies we found, including use of siblings of survivors as a control group, self-report methodology and lack of indications for prescriptions when prescribing data were used. This review has identified many mental health problems experienced by survivors of childhood cancer; however, the exact incidence, prevalence and risk-factors for their development remain unclear. Further work to identify childhood cancer patients who are at risk of developing late mental health morbidity is essential.
儿童癌症的发病率在增加，而存活率却在提高。因此，儿童癌症成年幸存者的数量也在增加。许多幸存者都遭受癌症治疗带来的长期后果。尽管这些后果有很多都有详细记录，但对于儿童癌症幸存者的心理健康状况却知之甚少。本文旨在使用系统综述方法描述成年儿童癌症幸存者的心理健康问题的流行率和范围。我们的综述包括 67 篇文章，描述了许多问题，包括抑郁、焦虑、行为问题和药物滥用。增加心理健康问题可能性的因素包括使用高剂量蒽环类药物、颅照射、肉瘤或中枢神经系统肿瘤的诊断以及持续的身体不健康。我们发现的研究有许多局限性，包括使用幸存者的兄弟姐妹作为对照组、自我报告方法以及在使用处方数据时缺乏处方说明。本综述确定了许多儿童癌症幸存者所经历的心理健康问题；然而，其确切的发病率、患病率和发病风险因素仍不清楚。进一步的工作是确定哪些儿童癌症患者有发展晚期心理健康疾病的风险。
