School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
J Gynecol Oncol. 2018 Mar;29(2):e32. doi: 10.3802/jgo.2018.29.e32.
Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains a therapeutic challenge. Thus, understanding the biology of chemoresistance is of great importance to overcome this challenge and will conceivably benefit the survival of ovarian cancer patients. Although mechanisms underlying the development of chemoresistance are still ambiguous, accumulating evidence has supported an integral role of cancer stem cells (CSCs) in recurrence following chemotherapy. Recently, tumor metabolism has gained interest as a reason of chemoresistance in tumors and chemotherapeutic drugs in combination with metabolism targeting approaches has been found promising in overcoming therapeutic resistance. In this review, we will summarize recent studies on CSCs and metabolism in ovarian cancer and discuss possible role of CSCs metabolism in chemoresistance.
卵巢癌是全球最致命的妇科恶性肿瘤。化疗是卵巢癌的主要治疗方法。尽管初始反应很有希望，但晚期患者的频繁复发仍然是一个治疗挑战。因此，了解化疗耐药性的生物学机制对于克服这一挑战非常重要，并且可以设想使卵巢癌患者受益。尽管导致化疗耐药性的机制仍不清楚，但越来越多的证据支持癌症干细胞 (CSC) 在化疗后复发中的重要作用。最近，肿瘤代谢已成为肿瘤化疗耐药性的原因之一，并且已经发现联合使用代谢靶向药物的化疗药物在克服治疗耐药性方面很有前景。在这篇综述中，我们将总结卵巢癌中 CSCs 和代谢的最新研究，并讨论 CSCs 代谢在化疗耐药性中的可能作用。
