一种来自盐地蒿（Artemisia halodendron Turcz. ex Bess.）的新型苯并呋喃
A new benzofuran from Artemisia halodendron Turcz. ex Bess.
作者信息
Sun Jinfeng, Zhou Wei, Wei Cheng-Xi, Zhang Zhihong, Jin Xuejun, Li Gao
机构信息
a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , PR China.
b Medical College , Inner Mongolia University for Nationalities , Tongliao , PR China.
出版信息
Nat Prod Res. 2019 Jan;33(2):226-232. doi: 10.1080/14786419.2018.1443098. Epub 2018 Feb 22.
A new benzofuran, methyl (2S,2″S,3'E)-[2-(1″-acetoxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl]acrylate (1), and 13 known compounds (2-14) were isolated from an ethanol extract of Artemisia halodendron Turcz. ex Bess. The chemical structures of these compounds were determined by 1D and 2D NMR (H-H COSY, HMBC, HMQC and NOESY) and HR-ESI-MS spectra, and results were compared with data from the literature. The effects of compounds 1-14 were measured on NF-κB activation, with compounds 2 and 3 exhibiting inhibitory activities against TNF-α-induced NF-κB reporter gene expression in HeLa cells from 10 to 100 μM.
从盐地蒿（Artemisia halodendron Turcz. ex Bess.）的乙醇提取物中分离得到一种新的苯并呋喃，即(2S,2″S,3'E)-[2-(1″-乙酰氧基丙烷-2-基)-2,3-二氢苯并呋喃-5-基]丙烯酸甲酯（1）以及13种已知化合物（2 - 14）。通过一维和二维核磁共振（氢-氢化学位移相关谱、异核多键相关谱、异核单量子相干谱和核欧沃豪斯效应谱）以及高分辨电喷雾电离质谱对这些化合物的化学结构进行了测定，并将结果与文献数据进行了比较。测定了化合物1 - 14对核因子κB（NF-κB）激活的影响，化合物2和3在10至100μM浓度下对HeLa细胞中肿瘤坏死因子-α（TNF-α）诱导的NF-κB报告基因表达具有抑制活性。
Zotero 插件