Jin Long, Zhou Wei, Hu Zhengyu, Huang Yanyan, Diao Shengbao, Sun Jinfeng, Li Gao
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China.
Nat Prod Res. 2024 Jan-Feb;38(1):146-151. doi: 10.1080/14786419.2022.2104273. Epub 2022 Jul 25.
A new megastigmane glycoside, (1,5,6,7)-megastigman-3,9-dione-7-en-6,11-diol 11---D-glucopyranoside (), and a new organic acid glycoside, methyl (4 )-4---D-glucopyranosyl-decanoate (), together with eight known compounds (-), were isolated from the aerial parts of Turcz. ex Bess. (Asteraceae). Their chemical structures were elucidated by 1 D and 2 D NMR and HR-ESI-MS spectra and DP4+ probability analysis. Among the identified compounds, compounds , and were isolated from the family Asteraceae, and compounds , and - were identified from the genus for the first time. All of the compounds were evaluated for their anticomplementary activity against the classical pathway (CP) and the alternative pathway (AP). Compounds and showed anticomplementary activity with the CH values of 0.31 ± 0.08 and 0.50 ± 0.09 mM, respectively.
从短星菊（Turcz. ex Bess.，菊科）的地上部分分离出一种新的巨大戟烷糖苷，即(1,5,6,7)-巨大戟-3,9-二酮-7-烯-6,11-二醇11-O-β-D-吡喃葡萄糖苷（），以及一种新的有机酸糖苷，即甲基(4)-4-O-β-D-吡喃葡萄糖基-癸酸酯（），同时还分离出8种已知化合物（-）。通过一维和二维核磁共振以及高分辨电喷雾电离质谱光谱和DP4 +概率分析对它们的化学结构进行了阐明。在鉴定出的化合物中，化合物、和是从菊科植物中分离得到的，化合物、和-是首次从短星菊属植物中鉴定出来的。对所有化合物针对经典途径（CP）和替代途径（AP）的抗补体活性进行了评估。化合物和表现出抗补体活性，其CH值分别为0.31±0.08和0.50±0.09 mM。
