National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Av. Brazil 4036, Manguinhos, 21040-361 - Rio de Janeiro - RJ, Brazil.
Laboratorio de Avaliacao e Sintese de Substancias Bioativas (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), PO Box 68023, 21941-902, Rio de Janeiro, RJ, Brazil.
Mini Rev Med Chem. 2018;18(15):1265-1269. doi: 10.2174/1389557518666180220122113.
Still now, for many forms of the disseminated cancers there is no curative therapy available. The discovery of novel active chemotherapeutic agents is largely essential to overcome this problem. Natural compounds polyphenols are mainly characterized by a huge structural variance; they can render them intrinsic dietary components due to their common occurrence in plants. Now-a-days, polyphenols (secondary metabolites) are characterized by a vast spectrum of physiological significance. From the past twenty years in the world of scientific research, polyphenols play an important role in a wide range of physiological processess. This review focuses on the development of polyphenols as antitumor agent in recent research studies.
目前，对于许多形式的转移性癌症，尚无有效的治疗方法。因此，迫切需要发现新的有效的化疗药物。天然化合物多酚主要具有巨大的结构差异；由于它们在植物中的普遍存在，它们可以使它们成为内在的饮食成分。如今，多酚（次生代谢物）具有广泛的生理意义。在过去的二十年里，多酚在世界范围内的科学研究中在许多生理过程中发挥了重要作用。这篇综述主要集中在最近的研究中多酚作为抗肿瘤药物的发展。
