Department of Chemical Engineering, University Rovira i Virgili, Av. Països Catalans 26, Campus Sescelades, 43007 Tarragona, Spain.
Research and Education Unit for Communication in Healthcare Department of Cardiac Surgery, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Curie Sklodowskiej St. 9, 85-094 Bydgoszcz, Poland.
Molecules. 2020 Jul 23;25(15):3342. doi: 10.3390/molecules25153342.
The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.
近年来，涉及天然药物的抗癌疗法的发展呈指数级增长。在对人类健康产生有益影响的天然化合物中，多酚类化合物因其在植物中的保护功能、作为食品添加剂的用途和出色的抗氧化特性，在癌症治疗方面显示出了潜在的应用前景。将通常比天然化合物更具侵略性的常规药物与多酚类化合物结合使用的可能性提供了非常有价值的优势，例如构建更有效的抗癌疗法，对人类健康的副作用更小。本综述展示了大量试验，其中多酚化合物单独或与其他药物联合使用在癌症的不同阶段（癌症起始、促进和生长或进展）发挥着至关重要的作用。此外，还强调了各种多酚在癌症治疗中的应用的未来方向。
