Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Province's Key Laboratory of Green Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.
Org Biomol Chem. 2018 Mar 14;16(11):1851-1859. doi: 10.1039/c8ob00147b.
An efficient method for the synthesis of isoquinolino[1,2-b]quinazolin-8-one derivatives and 12-methyl-12H-isoindolo[1,2-b]quinazoline-10-one derivatives is described herein. With rhodium catalysis, the desired products are obtained through a sequence reaction of C-H activation-based alkenylation and intramolecular aza-Heck-type cyclization. The developed method has a wide range of substrate tolerance under mild conditions and provides an alternative for the structural elaboration of quinazoline compounds.
本文描述了一种高效合成异喹啉并[1,2-b]喹唑啉-8(9H)-酮衍生物和 12-甲基-12H-异吲哚并[1,2-b]喹唑啉-10(11H)-酮衍生物的方法。在铑催化下，通过 C-H 活化基烯丙基化和分子内氮杂-Heck 型环化的序列反应得到目标产物。该方法在温和条件下具有广泛的底物耐受性，为喹唑啉类化合物的结构修饰提供了一种替代方法。
