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关注食欲。

A Spotlight on Appetite.

机构信息

Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.

Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.

出版信息

Neuron. 2018 Feb 21;97(4):739-741. doi: 10.1016/j.neuron.2018.01.050.

DOI:10.1016/j.neuron.2018.01.050
PMID:29470967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5965268/
Abstract

Remarkably few hormones have been identified that stimulate appetite. The recent discovery of asprosin, a hormone that activates AgRP neurons to increase food intake and body weight, begins to fill this gap (Duerrschmid et al., 2017; Romere et al., 2016).

摘要

值得注意的是,目前已鉴定出的能够刺激食欲的激素很少。最近发现的一种激素——增食欲素,可激活 AgRP 神经元,增加食物摄入和体重,这在一定程度上填补了这一空白(Duerrschmid 等,2017;Romere 等,2016)。

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本文引用的文献

1
Asprosin is a centrally acting orexigenic hormone.阿朴脂蛋白是一种中枢作用的促食欲激素。
Nat Med. 2017 Dec;23(12):1444-1453. doi: 10.1038/nm.4432. Epub 2017 Nov 6.
2
Ghrelin as a Survival Hormone.胃饥饿素作为一种生存激素。
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3
Asprosin, a Fasting-Induced Glucogenic Protein Hormone.阿朴脂蛋白,一种禁食诱导的生糖蛋白激素。
Cell. 2016 Apr 21;165(3):566-79. doi: 10.1016/j.cell.2016.02.063. Epub 2016 Apr 14.
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Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.AgRP神经元中Gs偶联的GPCR信号传导引发食物摄入量的持续增加。
Nat Commun. 2016 Jan 8;7:10268. doi: 10.1038/ncomms10268.
5
Congenital generalized lipodystrophies--new insights into metabolic dysfunction.先天性全身脂肪营养不良——对代谢功能障碍的新见解
Nat Rev Endocrinol. 2015 Sep;11(9):522-34. doi: 10.1038/nrendo.2015.123. Epub 2015 Aug 4.
6
20 years of leptin: human disorders of leptin action.瘦素二十年:人类瘦素作用紊乱
J Endocrinol. 2014 Oct;223(1):T63-70. doi: 10.1530/JOE-14-0480.
7
Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet.成年小鼠中胃饥饿素细胞的诱导消融不会降低食物摄入量、体重或对高脂饮食的反应。
Cell Metab. 2014 Jul 1;20(1):54-60. doi: 10.1016/j.cmet.2014.04.007. Epub 2014 May 15.
8
Neonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3' end of FBN1 gene.伴有先天性脂肪代谢障碍的马方综合征新生儿早衰变体是由FBN1基因3'端的突变引起的。
Eur J Med Genet. 2014 Apr;57(5):230-4. doi: 10.1016/j.ejmg.2014.02.012. Epub 2014 Mar 6.
9
Reduced body weight is a common effect of gene knockout in mice.体重减轻是小鼠基因敲除后的常见效应。
BMC Genet. 2008 Jan 8;9:4. doi: 10.1186/1471-2156-9-4.
10
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.神经肽Y/刺鼠相关蛋白(NPY/AgRP)神经元对成年小鼠的进食至关重要,但在新生小鼠中可被消融。
Science. 2005 Oct 28;310(5748):683-5. doi: 10.1126/science.1115524.