关注食欲。
A Spotlight on Appetite.
机构信息
Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.
Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
出版信息
Neuron. 2018 Feb 21;97(4):739-741. doi: 10.1016/j.neuron.2018.01.050.
Abstract
Remarkably few hormones have been identified that stimulate appetite. The recent discovery of asprosin, a hormone that activates AgRP neurons to increase food intake and body weight, begins to fill this gap (Duerrschmid et al., 2017; Romere et al., 2016).
摘要
值得注意的是，目前已鉴定出的能够刺激食欲的激素很少。最近发现的一种激素——增食欲素，可激活 AgRP 神经元，增加食物摄入和体重，这在一定程度上填补了这一空白（Duerrschmid 等，2017；Romere 等，2016）。
相似文献
1
A Spotlight on Appetite.关注食欲。
Neuron. 2018 Feb 21;97(4):739-741. doi: 10.1016/j.neuron.2018.01.050.
2
Asprosin is a centrally acting orexigenic hormone.阿朴脂蛋白是一种中枢作用的促食欲激素。
Nat Med. 2017 Dec;23(12):1444-1453. doi: 10.1038/nm.4432. Epub 2017 Nov 6.
3
Energy Regulation Mechanism and Therapeutic Potential of Asprosin.胰高血糖素原样肽-3 及其受体激动剂在多囊卵巢综合征治疗中的作用
Diabetes. 2020 Apr;69(4):559-566. doi: 10.2337/dbi19-0009.
4
Overexpression and ELISA-based detection of asprosin in cultured cells and mice.在培养细胞和小鼠中过表达和基于 ELISA 的 asporsin 检测。
STAR Protoc. 2022 Dec 16;3(4):101762. doi: 10.1016/j.xpro.2022.101762. Epub 2022 Oct 13.
5
AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons.刺鼠相关蛋白神经元可在食欲抑制状态下增加食物摄入量，并抑制厌食性臂旁核神经元。
J Neurosci. 2017 Sep 6;37(36):8678-8687. doi: 10.1523/JNEUROSCI.0798-17.2017. Epub 2017 Aug 7.
6
Asprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment.Asprosin：与烧伤后治疗中 ghrelin 和细胞因子网络表达的可能靶点有关。
Med Hypotheses. 2018 Sep;118:163-168. doi: 10.1016/j.mehy.2018.07.008. Epub 2018 Jul 7.
7
Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor.蛋白酪氨酸磷酸酶受体 δ 作为食欲素的受体发挥作用。
Cell Metab. 2022 Apr 5;34(4):549-563.e8. doi: 10.1016/j.cmet.2022.02.012. Epub 2022 Mar 16.
8
[Appetite regulation by ghrelin - a novel neuro-endocrine gastric peptide hormone in the gut-brain-axis].[胃饥饿素对食欲的调节——肠-脑轴中的一种新型神经内分泌胃肽激素]
Z Gastroenterol. 2003 Sep;41(9):929-36. doi: 10.1055/s-2003-41853.
9
Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism.内源性胃饥饿素在生长激素分泌、食欲调节及新陈代谢中的作用。
Rev Endocr Metab Disord. 2006 Dec;7(4):237-49. doi: 10.1007/s11154-006-9022-0.
10
Differential effects of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats.甲基苯丙胺对自由进食和定时喂食大鼠下丘脑神经肽Y mRNA表达以及血清瘦素和胃饥饿素浓度的不同影响。
Neuroscience. 2005;132(1):167-73. doi: 10.1016/j.neuroscience.2004.11.037.
引用本文的文献
1
Development of a mix-and-read assay for human asprosin using antibody-oligonucleotide probes and thermofluorimetric analysis.使用抗体-寡核苷酸探针和热荧光分析技术开发人嗜蛋白原混合读取检测法。
Anal Methods. 2024 Sep 12;16(35):6057-6063. doi: 10.1039/d3ay01175e.
2
Apelin-13 and Asprosin in Adolescents with Anorexia Nervosa and Their Association with Psychometric and Metabolic Variables.食欲抑制素-13 和天冬酰胺在神经性厌食症青少年中的作用及其与心理计量学和代谢变量的关系。
Nutrients. 2022 Sep 28;14(19):4022. doi: 10.3390/nu14194022.
3
Serum Asprosin Concentrations in Children with Prader-Willi Syndrome: Correlations with Metabolic Parameters.普拉德-威利综合征患儿的血清阿普洛辛浓度：与代谢参数的相关性
J Clin Med. 2022 Apr 18;11(8):2268. doi: 10.3390/jcm11082268.
4
Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature.阿普索辛——一种禁食诱导的、产糖的、食欲刺激的脂肪因子，作为一种有前途的新分子。它会成为肥胖症、糖尿病或不孕症治疗的新因素吗？文献综述。
Nutrients. 2021 Feb 14;13(2):620. doi: 10.3390/nu13020620.
5
Energy Regulation Mechanism and Therapeutic Potential of Asprosin.胰高血糖素原样肽-3 及其受体激动剂在多囊卵巢综合征治疗中的作用
Diabetes. 2020 Apr;69(4):559-566. doi: 10.2337/dbi19-0009.
6
Increased plasma asprosin levels in patients with drug-naive anorexia nervosa.初诊神经性厌食症患者血浆脑肠肽水平升高。
Eat Weight Disord. 2021 Feb;26(1):313-321. doi: 10.1007/s40519-020-00845-3. Epub 2020 Feb 5.
7
Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus.血清中阿普素水平升高，对葡萄糖波动的反应受损与 2 型糖尿病有关。
J Diabetes Investig. 2020 Mar;11(2):349-355. doi: 10.1111/jdi.13148. Epub 2019 Oct 3.
本文引用的文献
1
Asprosin is a centrally acting orexigenic hormone.阿朴脂蛋白是一种中枢作用的促食欲激素。
Nat Med. 2017 Dec;23(12):1444-1453. doi: 10.1038/nm.4432. Epub 2017 Nov 6.
2
Ghrelin as a Survival Hormone.胃饥饿素作为一种生存激素。
Trends Endocrinol Metab. 2017 Dec;28(12):843-854. doi: 10.1016/j.tem.2017.10.001. Epub 2017 Oct 30.
3
Asprosin, a Fasting-Induced Glucogenic Protein Hormone.阿朴脂蛋白，一种禁食诱导的生糖蛋白激素。
Cell. 2016 Apr 21;165(3):566-79. doi: 10.1016/j.cell.2016.02.063. Epub 2016 Apr 14.
4
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.AgRP神经元中Gs偶联的GPCR信号传导引发食物摄入量的持续增加。
Nat Commun. 2016 Jan 8;7:10268. doi: 10.1038/ncomms10268.
5
Congenital generalized lipodystrophies--new insights into metabolic dysfunction.先天性全身脂肪营养不良——对代谢功能障碍的新见解
Nat Rev Endocrinol. 2015 Sep;11(9):522-34. doi: 10.1038/nrendo.2015.123. Epub 2015 Aug 4.
6
20 years of leptin: human disorders of leptin action.瘦素二十年：人类瘦素作用紊乱
J Endocrinol. 2014 Oct;223(1):T63-70. doi: 10.1530/JOE-14-0480.
7
Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet.成年小鼠中胃饥饿素细胞的诱导消融不会降低食物摄入量、体重或对高脂饮食的反应。
Cell Metab. 2014 Jul 1;20(1):54-60. doi: 10.1016/j.cmet.2014.04.007. Epub 2014 May 15.
8
Neonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3' end of FBN1 gene.伴有先天性脂肪代谢障碍的马方综合征新生儿早衰变体是由FBN1基因3'端的突变引起的。
Eur J Med Genet. 2014 Apr;57(5):230-4. doi: 10.1016/j.ejmg.2014.02.012. Epub 2014 Mar 6.
9
Reduced body weight is a common effect of gene knockout in mice.体重减轻是小鼠基因敲除后的常见效应。
BMC Genet. 2008 Jan 8;9:4. doi: 10.1186/1471-2156-9-4.
10
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.神经肽Y/刺鼠相关蛋白（NPY/AgRP）神经元对成年小鼠的进食至关重要，但在新生小鼠中可被消融。
Science. 2005 Oct 28;310(5748):683-5. doi: 10.1126/science.1115524.
Zotero 插件