Alsaif Maha, Field Catherine J, Colin-Ramirez Eloisa, Prado Carla M, Haqq Andrea M
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R7, Canada.
Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R7, Canada.
J Clin Med. 2022 Apr 18;11(8):2268. doi: 10.3390/jcm11082268.
Children with Prader-Willi syndrome (PWS) are characterized by severe obesity. Asprosin is a newly discovered protein hormone produced by the white adipose tissue and is correlated with insulin resistance. The aim of our study was to describe the concentrations of serum asprosin in children with PWS compared to those with overweight/obesity and normal weight, and to explore the postprandial change in asprosin concentrations in participants with PWS and BMI-z matched controls. We enrolled 52 children, 23 with PWS, 8 with overweight/obesity, and 21 with normal weight. Fasting levels of asprosin, glucose, and insulin were collected in all children, and postprandial asprosin and fasting levels of acyl ghrelin (AG) and leptin were also determined in a subsample of participants. There were no significant differences among groups in fasting levels of asprosin, glucose, insulin, and HOMA-IR. Fasting serum asprosin and 1-h post-meal serum asprosin did not differ in children with PWS nor in BMI-z matched controls. Fasting asprosin showed an adjusted positive correlation with glucose in children with obesity (r = 0.93, = 0.007) but not in children with PWS nor children with normal weight. Circulating asprosin might be a predictor of early alterations in glucose metabolism in children with obesity. More research is needed to further explain the association between asprosin, food intake, metabolism, and obesity in PWS.
普拉德-威利综合征（PWS）患儿的特征是严重肥胖。阿朴脂蛋白是一种新发现的由白色脂肪组织产生的蛋白质激素，与胰岛素抵抗相关。我们研究的目的是描述PWS患儿与超重/肥胖及正常体重儿童相比血清阿朴脂蛋白的浓度，并探讨PWS患儿和体重指数Z评分匹配的对照组参与者餐后阿朴脂蛋白浓度的变化。我们招募了52名儿童，其中23名患有PWS，8名超重/肥胖，21名体重正常。收集了所有儿童的空腹阿朴脂蛋白、葡萄糖和胰岛素水平，并且还在部分参与者中测定了餐后阿朴脂蛋白以及空腹酰基胃泌素（AG）和瘦素水平。各组在空腹阿朴脂蛋白、葡萄糖、胰岛素和稳态模型评估胰岛素抵抗（HOMA-IR）水平上无显著差异。PWS患儿和体重指数Z评分匹配的对照组儿童的空腹血清阿朴脂蛋白和餐后1小时血清阿朴脂蛋白无差异。肥胖儿童空腹阿朴脂蛋白与葡萄糖呈校正正相关（r = 0.93，P = 0.007），但PWS患儿和体重正常的儿童则不然。循环阿朴脂蛋白可能是肥胖儿童葡萄糖代谢早期改变的一个预测指标。需要更多研究来进一步解释阿朴脂蛋白、食物摄入、代谢和PWS患儿肥胖之间的关联。
