Tan Liang, Huang Duo, Liu Bo, Ossowski Zbigniew, Wang Ning, Yan Weihua
Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland.
Sports Health and Industrial Development Research Center, School of Physical Education, Shangrao Normal University, 334001, Shangrao, China.
Int J Obes (Lond). 2025 May 16. doi: 10.1038/s41366-025-01777-7.
The purpose of this network meta-analysis (NMA) of randomized controlled trials (RCT) was to examine the effects of different exercise intensities on inflammatory markers in women with overweight/obesity.
A systematic search for RCTs that met the inclusion criteria for the period up to October 2024. random effects NMA was performed within a frequency-based framework.
A total of 75 RCTs were included (3989 participants). High-intensity exercise significantly modulated leptin and adiponectin levels, but had a nonsignificant effect on TNF-α, CRP, and IL-6 levels. Moderate-intensity exercise significantly modulated TNF-α, CRP, IL-6, leptin, and adiponectin levels. Surface under the cumulative ranking curve (SUCRA) probability ranking showed that moderate-intensity exercise was the most recommended exercise intensity for reducing TNF-α, CRP, IL-6, and leptin levels, and for modulating adiponectin levels, moderate-intensity exercise also had a SUCRA value of 65.4%, so we believe that moderate-intensity exercise may be the most robust type of exercise intensity in terms of the breadth of effects. Subgroup analysis showed that moderate-intensity aerobic exercise (MAE) significantly reduced TNF-α levels. Moderate-intensity resistance training (MRT) is the most recommended type for decreasing IL-6 and leptin levels. Moderate-intensity combined exercise (MCE) is the best type of exercise for managing CRP and adiponectin levels.
There were significant differences in the effects of different exercise intensities on specific inflammatory markers in women living with overweight and obesity. Moderate-intensity exercise may be the most robust type of exercise intensity. Future studies should consider the importance of exercise duration and volume (e.g., in MET* minutes/week) to better understand the relationship between exercise intensity and inflammatory markers. The effects of combining exercise and diet on inflammatory markers in women with overweight and obesity should also be explored in greater depth.
本随机对照试验（RCT）的网络荟萃分析（NMA）旨在研究不同运动强度对超重/肥胖女性炎症标志物的影响。
对截至2024年10月符合纳入标准的RCT进行系统检索。在基于频率的框架内进行随机效应NMA。
共纳入75项RCT（3989名参与者）。高强度运动显著调节了瘦素和脂联素水平，但对TNF-α、CRP和IL-6水平无显著影响。累积排序曲线下面积（SUCRA）概率排序显示，中等强度运动是降低TNF-α、CRP、IL-6和瘦素水平以及调节脂联素水平最推荐的运动强度，中等强度运动的SUCRA值也为65.4%，因此我们认为就效果的广度而言，中等强度运动可能是最有效的运动强度类型。亚组分析表明，中等强度有氧运动（MAE）显著降低了TNF-α水平。中等强度抗阻训练（MRT）是降低IL-6和瘦素水平最推荐的类型。中等强度联合运动（MCE）是控制CRP和脂联素水平的最佳运动类型。
不同运动强度对超重和肥胖女性特定炎症标志物的影响存在显著差异。中等强度运动可能是最有效的运动强度类型。未来的研究应考虑运动持续时间和运动量（如代谢当量*分钟/周）的重要性，以更好地理解运动强度与炎症标志物之间的关系。还应更深入地探讨运动与饮食相结合对超重和肥胖女性炎症标志物的影响。
