Shih Kuang-Chung, Kwok Ching-Fai
Division of Endocrinology and Metabolism, Department of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan.
Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
BMC Pediatr. 2018 Feb 22;18(1):80. doi: 10.1186/s12887-018-1025-y.
Improvements in insulin resistance and pancreatic β-cell function have been shown following exercise in adults with obesity; however, few adolescent-based studies have been conducted. This study examined the impact of exercise training on body fat and insulin sensitivity and secretion in overweight and obese adolescents.
The effects of a 12-week exercise program on the parameters of adiposity and glucose homeostasis were investigated in 47 overweight and obese male adolescents.
After the exercise training program, body weight, body mass index, waist circumference, and body fat were significantly decreased (P < 0.001). Improvements in insulin sensitivity (HOMA-IR: 1.40 vs. 0.86, P < 0.001) and the disposition index (5.84 vs. 12.77, P < 0.001) were also observed. Compared to baseline, oral glucose tolerance tests showed reduced glucose and insulin levels at all time points following the exercise training (all P < 0.001). Subgroup analysis of overweight and obese adolescents with abnormal glucose tolerance revealed that there was no difference in plasma glucose levels as compared to the lean group.
A 12-week exercise training is effective in reducing body fat and improving insulin sensitivity and secretion. In addition, the benefits of the exercise intervention were even experienced by those with impaired glucose tolerance.
在肥胖成年人中，运动后胰岛素抵抗和胰腺β细胞功能有所改善；然而，基于青少年的研究却很少。本研究探讨了运动训练对超重和肥胖青少年体脂、胰岛素敏感性及分泌的影响。
对47名超重和肥胖男性青少年进行了一项为期12周的运动计划，研究其对肥胖参数和葡萄糖稳态的影响。
运动训练计划后，体重、体重指数、腰围和体脂均显著降低（P < 0.001）。胰岛素敏感性（稳态模型评估的胰岛素抵抗指数：1.40对0.86，P < 0.001）和处置指数（5.84对12.77，P < 0.001）也有所改善。与基线相比，口服葡萄糖耐量试验显示运动训练后所有时间点的血糖和胰岛素水平均降低（均P < 0.001）。对糖耐量异常的超重和肥胖青少年进行亚组分析发现，与瘦组相比，其血糖水平无差异。
为期12周的运动训练可有效降低体脂，改善胰岛素敏感性和分泌。此外，糖耐量受损者也能从运动干预中获益。
