Department of Molecular Medicine, Sapienza University of Rome, 00161-Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Institute Pasteur -Italia, 00161-Rome, Italy; IRCCS, Neuromed, Pozzilli, 86077 IS, Italy.
Cytokine Growth Factor Rev. 2018 Aug;42:47-55. doi: 10.1016/j.cytogfr.2018.02.003. Epub 2018 Feb 14.
Three groups of innate lymphoid cells (ILCs) can be defined based on transcription factor requirements, cytokine production profiles, and roles in immunity. Given their strategic anatomical location into barrier tissues and the ability to rapidly produce cytokines and to cross-talk with other immune and non-immune cells, ILCs play fundamental functions in tissue homeostasis and regulation of immune responses. Several members of the chemokine family influence ILC tissue localization in the correct microenvironment by regulating their release from the bone marrow as well as their homing and retention in the tissues. In this review, we discuss the recent advances on how chemokine regulation of ILC tissue-positioning and functional interaction with other cells play essential roles in tissue-specific regulation of innate and adaptive immune responses.
根据转录因子要求、细胞因子产生谱和在免疫中的作用，可以将三组先天淋巴细胞 (ILC) 定义。鉴于它们位于屏障组织中的战略位置以及快速产生细胞因子和与其他免疫和非免疫细胞相互作用的能力，ILC 在组织稳态和免疫反应调节中发挥着重要作用。趋化因子家族的几个成员通过调节它们从骨髓中的释放以及它们在组织中的归巢和保留，来影响 ILC 在正确的微环境中的组织定位。在这篇综述中，我们讨论了趋化因子如何调节 ILC 的组织定位以及与其他细胞的功能相互作用，从而在组织特异性调节先天和适应性免疫反应中发挥重要作用的最新进展。
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