Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Margarete-Höppel-Platz 1, D - 97080 Würzburg, Germany.
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Margarete-Höppel-Platz 1, D - 97080 Würzburg, Germany.
Psychiatry Res Neuroimaging. 2018 Apr 30;274:11-18. doi: 10.1016/j.pscychresns.2018.02.003. Epub 2018 Feb 11.
The verbal fluency task (VFT) is a well-established cognitive marker for mild cognitive impairment (MCI) in the prodromal stage of Alzheimer´s dementia (AD). The behavioral VFT performance of patients allows the prediction of dementia two years later. But effective compensatory mechanism might cover or reduce the predictive value of the VFT. Therefore the aim of this study is to measure the hemodynamic response during VFT in patients with mild cognitive impairment (MCI) to establish the hemodynamic response during the VFT as a screening instrument for the prediction of dementia. One method which allows measuring the hemodynamic response during speech production without severe problems with moving artifacts like in functional magnetic resonance imaging (fMRI) is the functional near-infrared spectroscopy (fNIRS). It is optimal as a screening instrument, as it is easy to apply and without any contraindications. In this study we assessed the hemodynamic response in prefrontal and temporal regions in patients with MCI as well as matched healthy controls with fNIRS. We found a decreased hemodynamic response in the inferior frontotemporal cortex for the MCI group. Our results indicate that a frontotemporal decreased hemodynamic response could serve as a diagnostic biomarker for dementia.
言语流畅性任务（VFT）是阿尔茨海默病（AD）前驱期轻度认知障碍（MCI）的一种成熟的认知标志物。患者的行为 VFT 表现可以预测两年后的痴呆症。但是有效的补偿机制可能会掩盖或降低 VFT 的预测价值。因此，本研究旨在测量轻度认知障碍（MCI）患者在 VFT 期间的血液动力学反应，以确定 VFT 期间的血液动力学反应作为预测痴呆症的筛查工具。一种可以在不产生 fMRI 中严重运动伪影的情况下测量言语产生期间血液动力学反应的方法是功能近红外光谱（fNIRS）。它作为一种筛查工具是最佳的，因为它易于应用且没有任何禁忌症。在这项研究中，我们使用 fNIRS 评估了 MCI 患者以及匹配的健康对照组前额叶和颞叶区域的血液动力学反应。我们发现 MCI 组的下额颞叶皮质的血液动力学反应降低。我们的研究结果表明，额颞叶血液动力学反应降低可能作为痴呆症的诊断生物标志物。
