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Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin.海洋无脊椎动物相关细菌的共培养及跨学科技术助力新型抗生素凯西菌素的生物合成与发现。
ACS Chem Biol. 2017 Dec 15;12(12):3093-3102. doi: 10.1021/acschembio.7b00688. Epub 2017 Nov 22.
2
Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.来自海洋来源的哈氏小单孢菌SCSIO GJ089的抗微生物螺四环类代谢产物
J Nat Prod. 2017 May 26;80(5):1594-1603. doi: 10.1021/acs.jnatprod.7b00176. Epub 2017 May 10.
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antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification.antiSMASH 4.0——化学预测和基因簇边界识别的改进。
Nucleic Acids Res. 2017 Jul 3;45(W1):W36-W41. doi: 10.1093/nar/gkx319.
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Canu: scalable and accurate long-read assembly via adaptive -mer weighting and repeat separation.Canu：通过自适应k-mer加权和重复序列分离实现可扩展且准确的长读长序列拼接
Genome Res. 2017 May;27(5):722-736. doi: 10.1101/gr.215087.116. Epub 2017 Mar 15.
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Mechanism of Nucleophilic Activation of (-)-Lomaiviticin A.(-)-洛马维辛 A 的亲核活化机制。
J Am Chem Soc. 2016 Dec 7;138(48):15559-15562. doi: 10.1021/jacs.6b09657. Epub 2016 Nov 28.
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Complete genome sequencing and comparative analyses of broad-spectrum antimicrobial-producing Micromonospora sp. HK10.广谱抗菌小单孢菌HK10的全基因组测序及比较分析
Gene. 2016 Dec 5;594(1):97-107. doi: 10.1016/j.gene.2016.09.005. Epub 2016 Sep 5.
7
Pharmacogenetics of anthracyclines.蒽环类药物的药物遗传学
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Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM).基因组到天然产物的次生代谢产物预测信息学（PRISM）。
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9
Data, information, knowledge and principle: back to metabolism in KEGG.数据、信息、知识和原理：回到 KEGG 的代谢途径中。
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10
Insights into lomaiviticin biosynthesis. Isolation and structure elucidation of (-)-homoseongomycin.洛马维丁生物合成研究进展。(-)-同源鞘氨醇霉素的分离与结构鉴定。
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与海洋海绵相关的细菌微小单胞菌属菌株WMMA1996的基因组序列草图

Draft Genome Sequence of Micromonospora sp. Strain WMMA1996, a Marine Sponge-Associated Bacterium.

作者信息

Braun Doug R, Chevrette Marc G, Acharya Deepa D, Currie Cameron R, Rajski Scott R, Bugni Tim S

机构信息

Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

出版信息

Genome Announc. 2018 Feb 22;6(8):e00077-18. doi: 10.1128/genomeA.00077-18.

DOI:10.1128/genomeA.00077-18
PMID:29472337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5823995/
Abstract

sp. strain WMMA1996 was isolated in 2013 off the coast of the Florida Keys, United States, from a marine sponge as part of bacterial coculture-based drug discovery initiatives. Analysis of the ∼6.44-Mb genome reveals this microbe's potential role in the discovery of new drugs.

摘要

菌株WMMA1996于2013年在美国佛罗里达群岛海岸外从一种海洋海绵中分离出来，作为基于细菌共培养的药物发现计划的一部分。对约644万个碱基对的基因组分析揭示了这种微生物在新药发现中的潜在作用。