Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Blood. 2018 Feb 22;131(8):840-842. doi: 10.1182/blood-2018-01-824151.
In this issue of , Aschemeyer et al found that hepcidin bound to the central cavity of ferroportin (Fpn) and occluded its iron export activity, thereby revealing a previously unrecognized mechanism for Fpn regulation.
本期 杂志中,Aschemeyer 等人发现铁调素与亚铁转运蛋白(Fpn)的中央腔结合并阻断其铁输出活性,从而揭示了 Fpn 调节的一个先前未知的机制。