Teelmann K
Toxicol Lett. 1986 Nov;34(1):33-9. doi: 10.1016/0378-4274(86)90142-6.
The long-term (12 months) oral administration of the aromatic retinoid Ro 10-1670 (etretin) to dogs in relatively high doses of 5.0, 15.0 and 50.0/30.0 mg/kg/day was followed by acanthotic hyperplasia of the epidermis in the external auditory meatus and dose-dependent hypertrophy and/or hyperplasia of the canine ceruminous glands. These morphological changes were accompanied by a secretory stimulation on the ceruminous glands which was slight in the low-dose dogs but in the majority of the high-dose dogs reached a degree that was followed by secondary acute infectious inflammation. The alterations in the external auditory canal ceased almost immediately when treatment of dogs with the aromatic retinoid was stopped but recommenced when it was restarted.
给犬长期（12个月）口服芳香维甲酸Ro 10-1670（阿维A），剂量相对较高，分别为5.0、15.0和50.0/30.0mg/kg/天，结果外耳道表皮出现棘皮性增生，犬耵聍腺出现剂量依赖性肥大和/或增生。这些形态学变化伴有耵聍腺的分泌刺激，低剂量组犬的刺激较轻，但大多数高剂量组犬的刺激达到继发急性感染性炎症的程度。当停止用芳香维甲酸治疗犬时，外耳道的改变几乎立即停止，但重新开始治疗时又再次出现。
