心肌梗死与 p.Thr174Met 多态性：7657 例受试者的荟萃分析。
Myocardial Infarction and p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects.
机构信息
Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
出版信息
Cardiovasc Ther. 2021 May 3;2021:6667934. doi: 10.1155/2021/6667934. eCollection 2021.
BACKGROUND
It has been suggested that the a () gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. . In order to explore the relationship between p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted.
RESULTS
A significant association between p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, = 0.002), dominant (OR: 1.131, 95% CI: 1.016-1.260, = 0.024), codominant (OR: 2.198, 95% CI: 1.334-3.621, = 0.002), and additive (OR: 1.363, 95% CI: 1.132-1.641, = 0.001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models ( < 0.05). No significant association between p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup ( > 0.05).
CONCLUSIONS
p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of p.Thr174Met might confer the risk for MI.
背景
有人认为 a()基因 rs4762(p.Thr174Met)多态性可能与心肌梗死(MI)风险相关，但研究结果仍存在争议。为了探讨 p.Thr174Met 多态性与 MI 风险的关系，进行了本次包含 11 项独立研究的 7657 名受试者的荟萃分析。
结果
在隐性遗传模型（OR：2.26，95%CI：1.35-3.77， = 0.002）、显性遗传模型（OR：1.131，95%CI：1.016-1.260， = 0.024）、共显性遗传模型（OR：2.198，95%CI：1.334-3.621， = 0.002）和加性遗传模型（OR：1.363，95%CI：1.132-1.641， = 0.001）中，p.Thr174Met 多态性与 MI 显著相关。在亚洲亚组中，所有遗传模型下 MI 风险均显著增加（<0.05）。在高加索亚组中，p.Thr174Met 多态性与 MI 之间无显著相关性（>0.05）。
结论
p.Thr174Met 变体可能会增加 MI 风险，特别是在亚洲人群中。p.Thr174Met 多态性的 Met174 等位基因可能会增加 MI 的风险。
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