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基于低折射率聚合物光纤的高灵敏度表面等离子体共振生物传感器。

Highly sensitive surface plasmon resonance biosensor based on a low-index polymer optical fiber.

作者信息

Cao Shaoqing, Shao Yu, Wang Ying, Wu Tiesheng, Zhang Longfei, Huang Yijian, Zhang Feng, Liao Changrui, He Jun, Wang Yiping

出版信息

Opt Express. 2018 Feb 19;26(4):3988-3994. doi: 10.1364/OE.26.003988.

Abstract

A highly sensitive refractive index sensor based on surface plasmon resonance in a side-polished low-index polymer optical fiber is proposed for biosensing. Benefitting from the low refractive index of the fiber core, the sensitivity of the device can reach ~44567 nm/RIU theoretically for aqueous solutions, at the expense of a lowered upper detection limit that is down to ~1.340. The sensor is fabricated by coating 55-nm-thick Au-film on the polished surface of a graded-index perfluorinated polymer optical fiber. Results show that the sensor exhibits a sensitivity of ~22779 nm/RIU at 1.335 with a figure of merit of 61.2. When employed for glucose sensing, the sensor presents an averaged sensitivity of 24.50 nm/wt%, or 0.46 nm/mM. This device is expected to have potential applications in cost-effective bio- and chemical-sensing.

摘要

提出了一种基于侧面抛光低折射率聚合物光纤表面等离子体共振的高灵敏度折射率传感器用于生物传感。受益于纤芯的低折射率,该器件对于水溶液理论灵敏度可达约44567 nm/RIU,但代价是检测上限降低至约1.340。该传感器通过在渐变折射率全氟聚合物光纤的抛光表面涂覆55 nm厚的金膜制成。结果表明,该传感器在1.335时灵敏度约为22779 nm/RIU,品质因数为61.2。用于葡萄糖传感时,该传感器平均灵敏度为24.50 nm/ wt%,即0.46 nm/mM。该器件有望在具有成本效益的生物和化学传感中具有潜在应用。

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