Bissen Aidana, Yunussova Nigara, Myrkhiyeva Zhuldyz, Salken Aiganym, Tosi Daniele, Bekmurzayeva Aliya
National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan.
Front Bioeng Biotechnol. 2024 Jul 31;12:1401613. doi: 10.3389/fbioe.2024.1401613. eCollection 2024.
A biosensor is a promising alternative tool for the detection of clinically relevant analytes. Optical fiber as a transducer element in biosensors offers low cost, biocompatibility, and lack of electromagnetic interference. Moreover, due to the miniature size of optical fibers, they have the potential to be used in microfluidic chips and applications. The number of optical fiber biosensors are extensively growing: they have been developed to detect different analytes ranging from small molecules to whole cells. Yet the widespread applications of optical fiber biosensor have been hindered; one of the reasons is the lack of suitable packaging for their real-life application. In order to translate optical fiber biosensors into clinical practice, a proper embedding of biosensors into medical devices or portable chips is often required. A proper packaging approach is frequently as challenging as the sensor architecture itself. Therefore, this review aims to give an unpack different aspects of the integration of optical fiber biosensors into packaging platforms to bring them closer to actual clinical use. Particularly, the paper discusses how optical fiber sensors are integrated into flow cells, organized into microfluidic chips, inserted into catheters, or otherwise encased in medical devices to meet requirements of the prospective applications.
生物传感器是检测临床相关分析物的一种很有前景的替代工具。光纤作为生物传感器中的换能元件，具有成本低、生物相容性好和无电磁干扰等优点。此外，由于光纤尺寸微小，它们有潜力应用于微流控芯片及相关应用中。光纤生物传感器的数量正在广泛增长：它们已被开发用于检测从小分子到全细胞等不同的分析物。然而，光纤生物传感器的广泛应用受到了阻碍；原因之一是缺乏适合其实际应用的封装。为了将光纤生物传感器转化为临床实践，通常需要将生物传感器适当地嵌入医疗设备或便携式芯片中。一种合适的封装方法往往与传感器架构本身一样具有挑战性。因此，本综述旨在剖析光纤生物传感器集成到封装平台中的不同方面，使其更接近实际临床应用。特别是，本文讨论了光纤传感器如何集成到流通池中、组装成微流控芯片、插入导管中或以其他方式封装在医疗设备中，以满足预期应用的要求。
