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基于侧面抛光少模光纤的表面等离子体共振生物传感器。

Side-polished few-mode fiber based surface plasmon resonance biosensor.

作者信息

Dong Jiangli, Zhang Yaxin, Wang Yajun, Yang Fan, Hu Shiqi, Chen Yaofei, Zhu Wenguo, Qiu Wentao, Guan Heyuan, Lu Huihui, Yu Jianhui, Zhong Yongchun, Zhang Jun, Luo Yunhan, Chen Zhe

出版信息

Opt Express. 2019 Apr 15;27(8):11348-11360. doi: 10.1364/OE.27.011348.

Abstract

The fiber geometry, fiber parameters and mode-guiding properties are crucial for realizing high-performance fiber-based sensors. In this work, we propose and demonstrate a few-mode fiber (FMF)-based surface plasmon resonance (SPR) biosensor. The FMF-SPR sensor was fabricated via side-polishing a few-mode fiber and coating a thin layer of gold film, on the basis of the optimization of fiber geometry, thickness of the gold film and mode selection, which were performed with the finite element method. The refractive index (RI) sensing performance of three such sensors with different residual fiber thicknesses were investigated. In the RI range from 1.333 to 1.404, the highest sensitivity up to 4903 nm/RIU and a figure of merit of 46.1 RIU are achieved. For testing the bovine serum albumin (BSA) solution, an averaged BSA RI sensitivity of 6328 nm/RIU and an averaged BSA concentration sensitivity of 1.17 nm/(mg/ml) are realized. Benefiting from only a few modes supported in the FMF, a smaller line-width of the SPR spectrum is obtained, which further results in a higher figure of merit (FOM). Moreover, when combined with the superiority of the mode-multiplexing technology brought by the FMF, the FMF-SPR sensors may find applications in biochemical analysis with high performance and high throughputs.

摘要

光纤几何结构、光纤参数及模式引导特性对于实现高性能光纤传感器至关重要。在本工作中,我们提出并演示了一种基于少模光纤(FMF)的表面等离子体共振(SPR)生物传感器。通过对少模光纤进行侧面研磨并涂覆一层金薄膜来制作FMF-SPR传感器,这是在利用有限元方法对光纤几何结构、金薄膜厚度及模式选择进行优化的基础上进行的。研究了三种具有不同残余光纤厚度的此类传感器的折射率(RI)传感性能。在1.333至1.404的RI范围内,实现了高达4903 nm/RIU的最高灵敏度以及46.1 RIU的品质因数。对于牛血清白蛋白(BSA)溶液测试,实现了平均6328 nm/RIU的BSA RI灵敏度和平均1.17 nm/(mg/ml)的BSA浓度灵敏度。受益于FMF中仅支持的少数模式,获得了更窄的SPR光谱线宽,这进而导致更高的品质因数(FOM)。此外,当与FMF带来的模式复用技术优势相结合时,FMF-SPR传感器可能会在高性能和高通量的生化分析中找到应用。

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