Patterson Jillian A, Bowen Jennifer R, Francis Sally, Ford Jane B
Clinical and Population Perinatal Health Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia.
Sydney Medical School Northern, University of Sydney, Sydney, Australia.
BMC Pediatr. 2018 Feb 23;18(1):86. doi: 10.1186/s12887-018-1005-2.
Infants in Neonatal Intensive Care Units represent a heavily transfused population, and are the focus of much research interest. Such research commonly relies on custom research databases or routinely collected data. Knowledge of the accuracy of transfusion recording in these databases is important. This study aims to assess the reporting of red blood cell transfusion neonatal intensive care unit data compared with routinely collected hospital blood bank ("Blood Watch") data.
Blood Watch data was linked with the NICUS Data Collection, and with routinely collected birth and hospital data for births between 2007 and 2010. The sensitivity, specificity, and positive and negative predictive values for transfusion were calculated, compared to the Blood Watch data. The agreement between the NICUS and Blood Watch datasets on quantity transfused was also assessed.
Data was available on 3934 infants, of which 16.2% were transfused. Transfusion was reported in the NICUS Data Collection with high specificity (98.3%, 95% confidence interval (97.8%,98.7%)), but with some under-enumeration (sensitivity 89.2% (95% CI 86.5%,91.5%)). There was excellent agreement between the NICUS and Blood Watch datasets on quantity transfused (Kappa 0.90, 95% CI (0.88,0.92)). Transfusion reporting in the hospital data for these infants was also reliably reported (Sensitivity 83.7% (95% CI 80.6%,86.5%), specificity 99.1% (95% CI 98.7%,99.4%)).
Transfusion is reliably reported in the neonatal intensive care unit data, with some under-reporting, and quantity transfused is well recorded. The NICUS Data Collection provides useful information on blood transfusions, including quantity of blood transfused in a high risk population.
新生儿重症监护病房的婴儿是大量接受输血的群体，也是众多研究关注的焦点。此类研究通常依赖于定制研究数据库或常规收集的数据。了解这些数据库中输血记录的准确性很重要。本研究旨在评估新生儿重症监护病房红细胞输血数据报告与常规收集的医院血库（“血液监测”）数据的对比情况。
将血液监测数据与新生儿重症监护病房数据收集以及2007年至2010年出生及住院的常规收集数据相链接。与血液监测数据相比，计算输血的敏感性、特异性、阳性和阴性预测值。还评估了新生儿重症监护病房和血液监测数据集在输血量方面的一致性。
有3934名婴儿的数据可用，其中16.2%接受了输血。新生儿重症监护病房数据收集对输血的报告具有高特异性（98.3%，95%置信区间（97.8%，98.7%）），但存在一些漏报情况（敏感性89.2%（95%CI 86.5%，91.5%））。新生儿重症监护病房和血液监测数据集在输血量方面具有极好的一致性（Kappa 0.90，95%CI（0.88，0.92））。这些婴儿的医院数据中的输血报告也可靠（敏感性83.7%（95%CI 80.6%，86.5%），特异性99.1%（95%CI 98.7%，99.4%））。
新生儿重症监护病房数据中输血报告可靠，但存在一些漏报情况，且输血量记录良好。新生儿重症监护病房数据收集提供了有关输血的有用信息，包括高危人群的输血量。
