肾总体积：常染色体显性遗传性多囊肾病进展的最有价值预测指标。
Total kidney volume: the most valuable predictor of autosomal dominant polycystic kidney disease progression.
机构信息
Kidney Institute, Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Kidney Institute, Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
出版信息
Kidney Int. 2018 Mar;93(3):540-542. doi: 10.1016/j.kint.2017.10.027.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of kidney cysts resulting in damage to kidney structure and function. Yu et al. showed that height-adjusted total kidney volume (htTKV) was a significant independent predictor of ADPKD progression after a follow-up of 14.5 years. The genotype was not an independent prognostic factor after adjusting for htTKV. This commentary discusses several considerations in model comparison, biomarker validation, and future challenges in ADPKD research.
常染色体显性多囊肾病（ADPKD）的特征是肾脏囊肿的进行性发展，导致肾脏结构和功能受损。于等人研究表明，经过 14.5 年的随访，身高校正的总肾体积（htTKV）是 ADPKD 进展的一个显著独立预测因子。在调整 htTKV 后，基因型不是一个独立的预后因素。本评论讨论了模型比较、生物标志物验证以及 ADPKD 研究未来挑战中的几个注意事项。
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