Sridharan Kannan, Sivaramakrishnan Gowri
Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.
J Clin Neurosci. 2018 May;51:12-17. doi: 10.1016/j.jocn.2018.02.011. Epub 2018 Feb 21.
Sialorrhea is a common distress associated with certain neurological disorders. The aim of this study is to compare the pharmacological agents used for treating sialorrhea by network meta-analysis. Electronic databases were searched for randomized clinical trials comparing active drugs with either placebo or other active drugs. Total drooling scores was the primary outcome measure. Inverse variance heterogeneity model was used for both direct and mixed treatment comparison analysis. Twenty one studies were included in the systematic review and 15 in the meta-analysis. Compared to placebo, benztropine, botulinum toxins A and B are associated with a significant reduction in the frequency and severity of drooling both in the overall neurological disorders as well as for children with cerebral palsy. Only botulinum toxin A and B were associated with significant therapeutic effects in Parkinson's disease. Benztropine and botulinum toxins A and B were observed to be effective in reducing sialorrhea associated with neurological disorders.
流涎是一种与某些神经系统疾病相关的常见困扰。本研究的目的是通过网状Meta分析比较用于治疗流涎的药物制剂。检索电子数据库以查找将活性药物与安慰剂或其他活性药物进行比较的随机临床试验。总流口水评分是主要结局指标。采用逆方差异质性模型进行直接和混合治疗比较分析。系统评价纳入了21项研究，Meta分析纳入了15项研究。与安慰剂相比，苯海索、A型和B型肉毒毒素在总体神经系统疾病以及脑瘫儿童中均与流口水频率和严重程度的显著降低相关。仅A型和B型肉毒毒素在帕金森病中具有显著治疗效果。观察到苯海索以及A型和B型肉毒毒素在减少与神经系统疾病相关的流涎方面有效。
