Siewierska Katarzyna, Malicka Iwona, Kobierzycki Christopher, Paslawska Urszula, Cegielski Marek, Grzegrzolka Jedrzej, Piotrowska Aleksandra, Podhorska-Okolow Marzenna, Dziegiel Piotr, Wozniewski Marek
Department of Physiotherapy, University School of Physical Education, Wroclaw, Poland
Department of Physiotherapy, University School of Physical Education, Wroclaw, Poland.
In Vivo. 2018 Mar-Apr;32(2):249-254. doi: 10.21873/invivo.11231.
BACKGROUND/AIM: Physical exercise is increasingly considered by many authors to be a factor reducing the risk of cancer development and premature cancer-related death. Data indicate higher cure rates and longer times of survival in cancer patients who regularly exercise.
A total of 50 female Sprague-Dawley rats were used in the experiment. Animals at 1 month of age were intraperitoneally injected with N-methyl-N-nitrosourea. Three months following drug administration, rats underwent supervised physical training. The animals were divided into four groups: control untrained group and 3 groups trained with different intensities - i.e. low, moderate and high. Routine histopathological examination of tumors was performed and mitotic activity was assessed by immunohistochemical expression of the Ki-67 antigen.
Ki-67 antigen expression was observed in all analyzed tumors. The increase in Ki-67 antigen expression correlated positively with the increase in training intensity.
It can be assumed that low-intensity physical training is safe for patients with breast cancer. However, moderate- and high-intensity training may induce tumor cell proliferation worsening patients' prognosis.
背景/目的：许多作者越来越多地认为体育锻炼是降低癌症发生风险和癌症相关过早死亡风险的一个因素。数据表明，经常锻炼的癌症患者治愈率更高，生存期更长。
实验共使用50只雌性Sprague-Dawley大鼠。1月龄动物腹腔注射N-甲基-N-亚硝基脲。给药3个月后，大鼠接受有监督的体育训练。动物被分为四组：未训练的对照组和3个不同强度训练组，即低强度、中等强度和高强度。对肿瘤进行常规组织病理学检查，并通过Ki-67抗原的免疫组化表达评估有丝分裂活性。
在所有分析的肿瘤中均观察到Ki-67抗原表达。Ki-67抗原表达的增加与训练强度的增加呈正相关。
可以假定低强度体育训练对乳腺癌患者是安全的。然而，中等强度和高强度训练可能会诱导肿瘤细胞增殖，从而恶化患者的预后。
