Chen Haiyan, Zhou Huimin, Wu Bo, Lu Hanxiao, Zhang Jie, Zhang Yan, Gu Yuanlong, Zhou Guangwen, Xiang Jie, Yang Jun
Department of General Surgery, Affiliated Hospital of Jiangnan University, Jiangsu, China.
School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.
Liver Res. 2024 Mar 8;8(1):22-33. doi: 10.1016/j.livres.2024.03.001. eCollection 2024 Mar.
Sarcopenia and physical deconditioning are common complications in patients with liver cancer, which are frequently caused by insufficient physical activity and poor nutritional status, resulting in physical frailty and a significant impact on the patient's physical fitness. Notably, sarcopenia, frailty, and poor cardiopulmonary endurance have all been linked to higher mortality rates among patients with liver cancer. Exercise intervention significantly improves various health parameters in liver cancer patients, including metabolic syndrome, muscle wasting, cardiorespiratory endurance, health-related quality of life, and reduction in hepatic venous pressure gradient. However, the link between physical exercise and liver cancer is commonly overlooked. In this article, we will examine the impact of exercise on liver cancer and present the most recent evidence on the best types of exercise for various stages of liver cancer. This article also summarizes and discusses the molecular mechanisms that control metabolism and systemic immune function in tumors. In brief, physical exercise should be considered an important intervention in the prevention and treatment of liver cancer and its complications.
肌肉减少症和身体机能衰退是肝癌患者常见的并发症，通常由体力活动不足和营养状况不佳引起，导致身体虚弱，并对患者的身体健康产生重大影响。值得注意的是，肌肉减少症、身体虚弱和心肺耐力差都与肝癌患者较高的死亡率相关。运动干预可显著改善肝癌患者的各项健康参数，包括代谢综合征、肌肉萎缩、心肺耐力、健康相关生活质量以及降低肝静脉压力梯度。然而，体育锻炼与肝癌之间的联系通常被忽视。在本文中，我们将探讨运动对肝癌的影响，并介绍针对肝癌不同阶段的最佳运动类型的最新证据。本文还总结并讨论了控制肿瘤代谢和全身免疫功能的分子机制。简而言之，体育锻炼应被视为预防和治疗肝癌及其并发症的重要干预措施。
