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[SYNDROME OF OBSTRUCTIVE SLEEP APNEA IN THE ELDERLY POPULATION - PREVALENCE, CLINICAL CHARACTERISTICS AND TREATMENT STRATEGY].[老年人群阻塞性睡眠呼吸暂停综合征——患病率、临床特征及治疗策略]
Harefuah. 2017 Jan;156(1):41-44.
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Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences.睡眠呼吸暂停：类型、机制及临床心血管后果
J Am Coll Cardiol. 2017 Feb 21;69(7):841-858. doi: 10.1016/j.jacc.2016.11.069.
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Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: A systematic review.目前关于合并阻塞性睡眠呼吸暂停和慢性阻塞性肺疾病的患病率和临床结局的证据：系统评价。
Sleep Med Rev. 2017 Apr;32:58-68. doi: 10.1016/j.smrv.2016.02.007. Epub 2016 Mar 2.
4
Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipidemia and Overweight/Obese via Reducing ROCK2 Concentration.阿托伐他汀联合二甲双胍通过降低ROCK2浓度对血脂异常和超重/肥胖受试者具有附加益处。
Exp Clin Endocrinol Diabetes. 2016 Apr;124(4):246-50. doi: 10.1055/s-0035-1569364. Epub 2016 Apr 28.
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Sleep and Stroke.睡眠与中风
Sleep Med Clin. 2016 Mar;11(1):39-51. doi: 10.1016/j.jsmc.2015.10.009. Epub 2016 Jan 9.
6
Impact of Obstructive Sleep Apnea Syndrome on Endothelial Function, Arterial Stiffening, and Serum Inflammatory Markers: An Updated Meta-analysis and Metaregression of 18 Studies.阻塞性睡眠呼吸暂停综合征对内皮功能、动脉僵硬度和血清炎症标志物的影响：18项研究的最新荟萃分析和Meta回归分析
J Am Heart Assoc. 2015 Nov 13;4(11):e002454. doi: 10.1161/JAHA.115.002454.
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Clinical manifestations of sleep apnea.睡眠呼吸暂停的临床表现。
J Thorac Dis. 2015 Sep;7(9):E298-310. doi: 10.3978/j.issn.2072-1439.2015.09.13.
8
Increased RhoA/Rho-Kinase Activity and Markers of Endothelial Dysfunction in Young Adult Subjects with Metabolic Syndrome.代谢综合征青年受试者中RhoA/Rho激酶活性增加与内皮功能障碍标志物
Metab Syndr Relat Disord. 2015 Nov;13(9):373-80. doi: 10.1089/met.2015.0061.
9
Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea.阻塞性睡眠呼吸暂停是人群中的一种常见疾病——睡眠呼吸暂停流行病学综述。
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Rho kinase as a target for cerebral vascular disorders.作为脑血管疾病靶点的Rho激酶
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阻塞性睡眠呼吸暂停综合征患者外周血单个核细胞中ROCK1和ROCK2水平降低

Reduced Peripheral Blood Mononuclear Cell ROCK1 and ROCK2 Levels in Obstructive Sleep Apnea Syndrome.

作者信息

Aydin Şenay, Özdemir Cengiz, Küçükali Cem Ismail, Sökücü Sinem Nedime, Giriş Murat, Akcan Uğur, Tüzün Erdem

机构信息

Department of Neurology, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey.

Department of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey.

出版信息

In Vivo. 2018 Mar-Apr;32(2):319-325. doi: 10.21873/invivo.11240.

DOI:10.21873/invivo.11240
PMID:29475915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5905200/
Abstract

BACKGROUND/AIM: Obstructive sleep apnea syndrome (OSAS) is associated with intermittent episodes of hypoxia, endothelial dysfunction and associated cardiovascular problems. Our aim was to investigate whether OSAS-related hypoxia alters the expression of rho-associated protein kinase (ROCK), a marker of chronic hypoxia and endothelial dysfunction.

MATERIALS AND METHODS

ROCK1 and ROCK2 levels were measured by immunoblotting in peripheral blood mononuclear cells (PBMC) of 47 OSAS patients and 17 healthy controls.

RESULTS

OSAS patients showed significantly lower PBMC ROCK1 and ROCK2 levels than healthy controls in the morning, but not in the evening. ROCK1/2 levels were correlated with blood triglyceride, visceral adiposity index, minimum oxygen saturation, C-reactive protein concentration, lymphocyte levels and sleep efficiency.

CONCLUSION

Intermittent hypoxia induced by OSAS does not permanently alter ROCK protein expression levels. OSAS appears to be associated with endothelial dysfunction through inflammation and lipid metabolism pathways.

摘要

背景/目的：阻塞性睡眠呼吸暂停综合征（OSAS）与间歇性缺氧发作、内皮功能障碍及相关心血管问题有关。我们的目的是研究OSAS相关缺氧是否会改变Rho相关蛋白激酶（ROCK）的表达，ROCK是慢性缺氧和内皮功能障碍的标志物。

材料与方法

通过免疫印迹法检测47例OSAS患者和17例健康对照者外周血单核细胞（PBMC）中的ROCK1和ROCK2水平。

结果

OSAS患者早晨的PBMC中ROCK1和ROCK2水平显著低于健康对照者，但晚上则无此差异。ROCK1/2水平与血甘油三酯、内脏脂肪指数、最低血氧饱和度、C反应蛋白浓度、淋巴细胞水平和睡眠效率相关。

结论

OSAS诱导的间歇性缺氧不会永久性改变ROCK蛋白表达水平。OSAS似乎通过炎症和脂质代谢途径与内皮功能障碍相关。