不同类型泌尿系统肿瘤患者尿氨基酸模式的差异 尿氨基酸模式作为泌尿系统肿瘤的标志物
Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors.
作者信息
Duskova Katerina, Vesely Stepan, DO Carmo Silva Joana, Cernei Natalia, Zitka Ondrej, Heger Zbynek, Adam Vojtech, Havlova Klara, Babjuk Marek
机构信息
Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic
Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic.
出版信息
In Vivo. 2018 Mar-Apr;32(2):425-429. doi: 10.21873/invivo.11257.
BACKGROUND
Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors.
MATERIALS AND METHODS
Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21).
RESULTS
In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma.
CONCLUSION
Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.
背景
目前使用的诊断方法特异性和侵入性不足，因此需要新的泌尿系统肿瘤标志物。本研究的目的是寻找氨基酸尿排泄与泌尿系统肿瘤存在之间的联系。
材料与方法
我们使用离子交换色谱法检测了前列腺癌患者（n = 30）、膀胱癌患者（n = 28）、肾细胞癌患者（n = 16）以及健康志愿者（对照组；n = 21）的尿液样本。
结果
在每一组中，我们都发现了一组与对照组相比浓度不同的氨基酸。这些差异在前列腺癌患者的肌氨酸中最为显著；在膀胱癌患者中为亮氨酸、苯丙氨酸和精氨酸；在肾细胞癌患者中为肌氨酸、谷氨酸、甘氨酸、酪氨酸和精氨酸。
结论
我们的研究结果表明尿液中特定类型氨基酸的出现与泌尿系统肿瘤的存在之间可能存在联系。
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