Le Moli S, Paganelli R, Sirianni M C, Nisini R, Quinti I, Seminara R, D'Amelio R, Aiuti F
Boll Ist Sieroter Milan. 1986;65(4):283-9.
In this paper the in vitro effects of lysozyme on several immunological function was investigated. Henn-egg-white lysozyme (at concentrations ranging between 1 and 10 micrograms/ml) has shown an inhibitory action on mitogen-induced lymphoblastigenesis and autologus mixed lymphocyte reaction. On the other hand, NK activity against K 562 cell line resulted to be increased in the presence of lysozyme. In addition lysozyme has shown to behave as chemokinetic factor increasing PMN random locomotion and inhibiting PMN response only towards complement derived chemotaxins, whereas there was no effect against other chemotactic factors. Then, in addition to its enzymatic activity, a role of lysozyme as modulator of the inflammatory response may be proposed.
本文研究了溶菌酶对几种免疫功能的体外作用。鸡蛋清溶菌酶（浓度范围为1至10微克/毫升）对有丝分裂原诱导的淋巴细胞生成和自体混合淋巴细胞反应显示出抑制作用。另一方面，在溶菌酶存在的情况下，对K562细胞系的自然杀伤（NK）活性有所增加。此外，溶菌酶表现为化学动力学因子，可增加中性粒细胞的随机运动，并且仅抑制中性粒细胞对补体衍生趋化因子的反应，而对其他趋化因子没有影响。因此，除了其酶活性外，溶菌酶可能还具有作为炎症反应调节剂的作用。
