Barabash R D, Ermakova T A, Bondarenko V S, Bondarenko E I, Vakulenko L B
Biull Eksp Biol Med. 1980;89(1):40-2.
The cooperation of specific and nonspecific factors of humoral immunity in the regulation of granulocyte locomotion was studied. Bacterial antigens of dental plaque, immunoglobulins, lysozyme, peroxidase, ribonuclease and trypsin were found to moderately stimulate chemotaxis and granulocyte chemokinesis. Of these, the most pronounced chemotactic effect is induced by ribonuclease and chemokinetic one by lysozyme. The strongest chemotactic stimulus is generated during activation of complement by the classical pathway. Production of the complement chemotactic factor by the classical pathway was dramatically increased by lysozyme and decreased by ribonuclease and trypsin. The treatment of granulocytes with antimicrobial enzymes diminishes their susceptibility to the chemotactic factor.
研究了体液免疫的特异性和非特异性因素在粒细胞运动调节中的协同作用。发现牙菌斑的细菌抗原、免疫球蛋白、溶菌酶、过氧化物酶、核糖核酸酶和胰蛋白酶可适度刺激趋化性和粒细胞化学运动性。其中，核糖核酸酶诱导的趋化作用最明显，溶菌酶诱导的化学运动作用最明显。经典途径激活补体时产生最强的趋化刺激。溶菌酶可显著增加经典途径补体趋化因子的产生，核糖核酸酶和胰蛋白酶则使其减少。用抗菌酶处理粒细胞会降低其对趋化因子的敏感性。
